Liver Transplantation for Hepatocellular Carcinoma: Prognostic Impact of Complete Pathologic Response and Influence of Treatment Modality—A US National Database Study
complete pathologic responsehepatocellular carcinomaliver transplantationlocoregional therapyyttrium-90
Highlights
- Complete pathologic response (cPR) occurs in approximately one-third of HCC patients undergoing liver transplantation and is strongly associated with improved overall and recurrence-free survival.
- Yttrium-90 (Y-90) radioembolization and ablation therapies independently increase cPR rates compared to transarterial chemoembolization (TACE), with Y-90 showing the greatest efficacy especially when administered early within six months of waitlisting.
- Imaging-based assessments frequently overestimate treatment response, highlighting the importance of pathological evaluation for accurate prognosis.
- Predictors of cPR include lower tumor burden, normal or moderately elevated alpha-fetoprotein (AFP) levels, longer waitlist times, and specific locoregional treatment choice.
Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.