Integrated 40-Gene Expression Profile Enhances Prognostic Precision and Guides Adjuvant Radiation in High-Risk Cutaneous Squamous Cell Carcinoma
risk stratificationadjuvant radiation therapygene expression profilecutaneous squamous-cell carcinoma
Highlight
- The integrated 40-gene expression profile (i40-GEP) combines tumor biology with clinicopathologic features to improve prognostic accuracy in high-risk cutaneous squamous cell carcinoma (HRcSCC).
- i40-GEP categorizes patients into four risk classes, identifying those at highest risk (Class 2B) with significantly poorer 3-year metastasis-free survival.
- Class 2B patients demonstrate a clear benefit from adjuvant radiation therapy (ART), supporting more personalized treatment approaches.
- i40-GEP outperforms individual clinicopathologic factors in predicting metastasis and local recurrence, enabling improved clinical decision-making.
Study Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.