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An umbrella review synthesizes evidence from 156 RCTs assessing probiotics’ effects on cognitive-related outcomes, showing moderate- to high-quality support for cognitive benefits but highlighting need for further trials on strains an
This systematic review and meta-analysis of randomized controlled trials finds no significant association between proton pump inhibitor use and increased risk of Clostridioides difficile infection, challenging earlier observational data and
Combining MRI and CT improves detection of nonviable disappearing colorectal liver metastases but does not reliably confirm nonviability, challenging the management of such lesions post-chemotherapy.
This review synthesizes evidence comparing postoperative pulmonary complications (PPCs) between robot-assisted surgery (RAS) and conventional laparoscopic surgery (CLS) in abdominal procedures, highlighting the pivotal role of ventilation d
A 6-week multimodal prehabilitation program combining exercise and nutrition significantly reduces postoperative morbidity in sarcopenic patients undergoing major liver resection, highlighting a promising strategy to improve surgical outcom
Metabolic dysfunction and MASLD elevate hepatocellular carcinoma risk in chronic hepatitis B patients. The PAGE-B score effectively stratifies this risk, especially in non-cirrhotic patients, while cirrhotic patients still require careful m
The EASI trial compared a once-daily 1600 mg 5-ASA tablet with the conventional three 800 mg tablet regimen for ulcerative colitis, finding similar adherence and relapse rates, suggesting a feasible simpler alternative.
The IL23R1142G>A genetic variant strongly predicts paradoxical psoriasis in inflammatory bowel disease patients undergoing anti-TNFα therapy, guiding personalized treatment decisions.
This meta-analysis reveals that short-term mortality in severe alcohol-associated hepatitis remains high, with no significant improvement over the past four decades despite advances in care, underscoring the urgent need for better therapies
In primary biliary cholangitis (PBC) patients treated with obeticholic acid (OCA), biochemical non-response strongly predicts a higher risk of clinical events including liver decompensation and mortality, underscoring the need for improved
Altered gut microbiota composition and metabolism exacerbate cirrhotic portal hypertension, highlighting potential microbiome-targeted therapies to mitigate disease progression.
This study demonstrates that empirical donor exclusion combined with a two-dose capsule regimen significantly improves cure rates in Clostridioides difficile infection treated with encapsulated faecal microbiota transplantation (FMT).
One in five UK patients with Rome IV IBS regularly use opioids, associated with worse quality of life, more psychological distress, and increased healthcare costs, highlighting a critical need for opioid stewardship in IBS management.
A phase 2b trial demonstrates that several noninvasive tests reliably reflect treatment response to semaglutide in patients with metabolic dysfunction-associated steatohepatitis, correlating with histologic improvements over 72 weeks.
A recent cross-sectional study reveals that alterations in gut microbiota correlate more strongly with impaired health-related quality of life in IBD patients than clinical disease activity, suggesting novel microbial therapeutic targets be
The FDA has approved golimumab (Simponi) for treating moderately to severely active ulcerative colitis in children weighing at least 15 kg, based on the PURSUIT 2 phase 3 study demonstrating significant clinical remission and safety.
A large Nordic study finds menopausal hormone therapy reduces the risk of esophageal and gastric cancers by up to 30%, especially with combined estrogen-progestin systemic formulations.
A recent trial assessing intravenous versus oral rehydration in children with severe acute malnutrition and gastroenteritis found no mortality difference at 96 hours, challenging fears of fluid overload and supporting cautious consideration
A 45-year-old male presents with cholestatic liver enzyme elevation and pruritus, diagnosed with primary sclerosing cholangitis confirmed by imaging and liver biopsy. Clinical management and prognosis are discussed.
Cendakimab, a monoclonal antibody targeting IL-13, shows significant improvements in symptoms, histologic response, and endoscopic features in eosinophilic esophagitis, with a tolerable safety profile through 48 weeks.
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