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Enhancing Lung Cancer Screening Adherence: Insights from a Randomized Clinical Trial of Health Communication and Stepped Reminder Interventions

Clinical Updatestruyền thông sức khỏe肺がん検診、段階的リマインダー、健康コミュニケーション、ランダム化臨床試験

Enhancing Lung Cancer Screening Adherence: Insights from a Randomized Clinical Trial of Health Communication and Stepped Reminder Interventions

By MedXY|Aug 12, 2026

A landmark randomized trial demonstrates that multilevel stepped reminders targeting both primary care physicians and patients markedly improve adherence to annual lung cancer screening, while health communication alone may be insufficient

Connectivity- vs Scalp-Based Targeting of Accelerated Transcranial Magnetic Stimulation for Depression: A Randomized Clinical Trial

transcranial magnetic stimulation

depression

Connectivity- vs Scalp-Based Targeting of Accelerated Transcranial Magnetic Stimulation for Depression: A Randomized Clinical Trial

By MedXY|Aug 10, 2026

This randomized trial compared connectivity-based versus scalp-based targeting of accelerated TMS in treatment-resistant depression, showing greater antidepressant effects with individualized connectivity-guided targeting.

Evaluating Low-Dose Colchicine for Preventing Vascular Events After Acute Intracerebral Hemorrhage: Insights from a Placebo-Controlled Pilot Trial

Cardiologyvascular events preventionrandomized clinical trial

Evaluating Low-Dose Colchicine for Preventing Vascular Events After Acute Intracerebral Hemorrhage: Insights from a Placebo-Controlled Pilot Trial

By MedXY|Aug 9, 2026

This pilot randomized trial demonstrates the feasibility of using low-dose colchicine after acute intracerebral hemorrhage to prevent vascular events, highlighting considerations for future larger studies regarding recruitment, adherence, a

Improved Survival in Unresectable Hepatocellular Carcinoma with Combined Transarterial Chemoembolization and Thermal Ablation: Insights from the Phase 3 TORCH Trial

Gastroenterologyhepatocellular carcinomarandomized clinical trial

Improved Survival in Unresectable Hepatocellular Carcinoma with Combined Transarterial Chemoembolization and Thermal Ablation: Insights from the Phase 3 TORCH Trial

By MedXY|Jul 30, 2026

The phase 3 TORCH trial demonstrates that adding selective radiofrequency ablation after transarterial chemoembolization significantly improves progression-free and overall survival in patients with unresectable liver-confined hepatocellula

Comparative Effectiveness of Dialectical Behavior Therapy and Schema Therapy in Borderline Personality Disorder: Insights from the BOOTS Trial

newsBorderline Personality Disorderrandomized clinical trial

Comparative Effectiveness of Dialectical Behavior Therapy and Schema Therapy in Borderline Personality Disorder: Insights from the BOOTS Trial

By MedXY|Jul 14, 2026

The BOOTS multicenter RCT found no significant difference in long-term effectiveness between dialectical behavior therapy (DBT) and schema therapy (ST) for borderline personality disorder (BPD), with both treatments yielding substantial cli

Adolescent Mental Health Care and Stigma: Insights from the ARTEMIS Randomized Clinical Trial and Complementary Evidence

Clinical Updatesadolescent mental healthcommunity intervention

Adolescent Mental Health Care and Stigma: Insights from the ARTEMIS Randomized Clinical Trial and Complementary Evidence

By MedXY|Jul 12, 2026

This review synthesizes evidence from the ARTEMIS trial and related studies on community-based adolescent mental health care and stigma reduction, highlighting intervention efficacy, implementation challenges, and translational potentials i

Middle Meningeal Artery Embolization with n-Butyl Cyanoacrylate: A New Standard for Chronic Subdural Hematoma Management?

Neurologychronic subdural hematomamiddle meningeal artery embolization

Middle Meningeal Artery Embolization with n-Butyl Cyanoacrylate: A New Standard for Chronic Subdural Hematoma Management?

By MedXY|Jul 3, 2026

A multicenter randomized trial shows that middle meningeal artery embolization with n-butyl cyanoacrylate, adjunct to standard care, significantly reduces recurrence and reoperation rates in chronic subdural hematoma without increasing adve

Efficacy and Safety of Mirtazapine in Treating Methamphetamine Use Disorder: Insights from a Phase 3 Randomized Clinical Trial

newsMethamphetamine Use DisorderMirtazapine

Efficacy and Safety of Mirtazapine in Treating Methamphetamine Use Disorder: Insights from a Phase 3 Randomized Clinical Trial

By MedXY|Jul 2, 2026

This randomized clinical trial evaluated mirtazapine’s safety and efficacy for methamphetamine use disorder, revealing a modest but statistically significant reduction in methamphetamine use without unexpected adverse events, offering

Ultra-Early Remote Ischemic Postconditioning After Thrombectomy Appears Safe but Does Not Improve 90-Day Stroke Recovery

Emergency Medicineacute ischemic strokeEndovascular Thrombectomy

Ultra-Early Remote Ischemic Postconditioning After Thrombectomy Appears Safe but Does Not Improve 90-Day Stroke Recovery

By MedXY|Jun 10, 2026

In the EnTRIPS randomized trial, ultra-early remote ischemic postconditioning after successful endovascular thrombectomy was safe but did not significantly improve 90-day functional independence in acute ischemic stroke.

Food Delivery After Heart Failure Hospitalization Was Feasible but Did Not Reduce 90-Day HF Readmissions

Cardiologyfresh produceheart failure

Food Delivery After Heart Failure Hospitalization Was Feasible but Did Not Reduce 90-Day HF Readmissions

By MedXY|Jun 10, 2026

A randomized trial found that medically tailored meals and fresh produce were highly feasible after HF hospitalization, but neither strategy improved the primary 90-day heart failure utilization outcome versus usual care.

Deprescribing Intervention Reduces Proton Pump Inhibitor Use in Primary Care

Family Medicine & NutritionBệnh trào ngược dạ dày thực quảndeprescribing

Deprescribing Intervention Reduces Proton Pump Inhibitor Use in Primary Care

By MedXY|Jun 6, 2026

A large primary care trial found that a combined patient- and GP-focused deprescribing intervention safely reduced long-term proton pump inhibitor use more effectively than usual care or GP-only education.

Ecopipam Reduced Relapse Risk in Pediatric Tourette Syndrome Without Metabolic or Extrapyramidal Signal in a Phase 3 Randomized Withdrawal Trial

Neurologydopamine D1 antagonistecopipam

Ecopipam Reduced Relapse Risk in Pediatric Tourette Syndrome Without Metabolic or Extrapyramidal Signal in a Phase 3 Randomized Withdrawal Trial

By MedXY|Jun 5, 2026

In a phase 3 randomized withdrawal trial, ecopipam maintained tic improvement in pediatric Tourette syndrome over 24 weeks and showed a generally favorable safety profile without clinically meaningful weight, metabolic, or drug-induced move

Fovinaciclib for First-Line Therapy of Advanced Breast Cancer: A Randomized Clinical Trial

newsaromatase inhibitorbreast cancer

Fovinaciclib for First-Line Therapy of Advanced Breast Cancer: A Randomized Clinical Trial

By MedXY|Jun 3, 2026

Adding fovinaciclib to first-line aromatase inhibitor therapy significantly prolonged progression-free survival in hormone receptor-positive, ERBB2-negative advanced breast cancer with manageable toxicity and preserved quality of life.

Interleukin 6 as a Treatment Target for Depression: A Proof-of-Concept Randomized Clinical Trial

newsdepressioninflammation

Interleukin 6 as a Treatment Target for Depression: A Proof-of-Concept Randomized Clinical Trial

By MedXY|Jun 2, 2026

A small randomized trial found that blocking IL-6 with tocilizumab showed promising, clinically meaningful trends for inflammation-related, hard-to-treat depression, especially for somatic symptoms, fatigue, anxiety, and quality of life, th

Effect of Electroacupuncture on Postherpetic Neuralgia: A Randomized Clinical Trial

Neurologyelectroacupunctureneuropathic pain

Effect of Electroacupuncture on Postherpetic Neuralgia: A Randomized Clinical Trial

By MedXY|May 28, 2026

A randomized clinical trial found that electroacupuncture reduced pain more than sham treatment in postherpetic neuralgia, with benefits lasting at least one month and no major safety concerns.

Rapid Respiratory Point-of-Care Testing and Antibiotic Use in Primary Care: A Randomized Clinical Trial

Family Medicine & Nutritionantibiotic stewardshipPoint-of-Care Testing

Rapid Respiratory Point-of-Care Testing and Antibiotic Use in Primary Care: A Randomized Clinical Trial

By MedXY|May 26, 2026

A randomized trial found that rapid respiratory point-of-care testing did not reduce same-day antibiotic prescribing in primary care, though it was safe and may help when a virus is detected.

Effectiveness of Automatically-Adjusted vs Manually-Adjusted Noninvasive Ventilation in Obesity Hypoventilation Syndrome: A Randomized Clinical Trial

Internal Medicinenoninvasive ventilationobesity hypoventilation syndrome

Effectiveness of Automatically-Adjusted vs Manually-Adjusted Noninvasive Ventilation in Obesity Hypoventilation Syndrome: A Randomized Clinical Trial

By MedXY|May 21, 2026

In ambulatory patients with obesity hypoventilation syndrome, automatically-adjusted noninvasive ventilation was as effective as manually adjusted NIV over 12 months and more cost-effective, offering a simpler path to treatment.

Fixed-Dose Tavapadon for Early Parkinson Disease: A Randomized Clinical Trial

NeurologyDopamine Agonistneurology

Fixed-Dose Tavapadon for Early Parkinson Disease: A Randomized Clinical Trial

By MedXY|May 20, 2026

In a phase 3 trial, once-daily tavapadon improved motor symptoms in people with early Parkinson disease and was generally well tolerated, with nausea, headache, and dizziness as the most common side effects.

Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression: The EPISODE Randomized Clinical Trial

newspsilocybinpsychiatry

Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression: The EPISODE Randomized Clinical Trial

By MedXY|May 18, 2026

Psilocybin-assisted psychotherapy showed promising but inconclusive antidepressant effects in treatment-resistant depression, with notable acute adverse events and safety concerns.

A CBT-Based Mobile App Significantly Reduced Tinnitus Distress in a Sham-Controlled Randomized Trial

newsCognitive Behavioral Therapydigital therapeutic

A CBT-Based Mobile App Significantly Reduced Tinnitus Distress in a Sham-Controlled Randomized Trial

By MedXY|May 11, 2026

In a 60-patient randomized trial, a digital therapeutic app delivering tinnitus education and CBT elements produced large, durable reductions in tinnitus-related distress over 16 weeks, with no serious safety concerns.

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