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Postoperative Oral Dexamethasone Reduces Pain and Opioid Use in Pediatric Tonsillectomy

Otorhinolaryngologydexamethasonepain management

Postoperative Oral Dexamethasone Reduces Pain and Opioid Use in Pediatric Tonsillectomy

By MedXY|Jul 29, 2026

A quadruple-blinded RCT found that oral dexamethasone given after pediatric tonsillectomy modestly reduced pain and substantially lowered opioid prescriptions, without increasing complications.

Nitrous Oxide as an Effective Analgesic in Office Operative Hysteroscopy: Insights from a Randomized Controlled Trial

newsAnalgesiaNitrous Oxide

MedXY News - pain management

Nitrous Oxide as an Effective Analgesic in Office Operative Hysteroscopy: Insights from a Randomized Controlled Trial

By MedXY|Jul 5, 2026

This randomized placebo-controlled trial demonstrates that inhaled nitrous oxide significantly reduces pain and enhances patient satisfaction during office operative hysteroscopy, especially in postmenopausal women, while improving procedur

Effect of Electroacupuncture on Postherpetic Neuralgia: A Randomized Clinical Trial

Neurologyelectroacupunctureneuropathic pain

Effect of Electroacupuncture on Postherpetic Neuralgia: A Randomized Clinical Trial

By MedXY|May 28, 2026

A randomized clinical trial found that electroacupuncture reduced pain more than sham treatment in postherpetic neuralgia, with benefits lasting at least one month and no major safety concerns.

Geographic Disparities in Opioid Prescribing Patterns for Toothache Pain in the United States

Anesthesiologygeographic variationopioid prescribing

Geographic Disparities in Opioid Prescribing Patterns for Toothache Pain in the United States

By MedXY|Apr 27, 2026

A national study reveals significant state-level and urban-rural variations in opioid prescribing following toothache diagnoses, with 15 states exceeding the national average and rural areas showing slightly lower prescription rates.

Addressing the Invisible Crisis: Symptom Flares, Self-Management Barriers, and Clinical Gaps in Endometriosis Care

Clinical UpdatesendometriosisGiao tiếp Lâm sàng

Addressing the Invisible Crisis: Symptom Flares, Self-Management Barriers, and Clinical Gaps in Endometriosis Care

By MedXY|Mar 22, 2026

This review synthesizes new evidence on endometriosis symptom flares, highlighting a significant gap between patient burden and professional guidance, while integrating the latest meta-analytic findings on pharmacologic pain interventions.

Compartment-Specific Knee Bracing Improves Outcomes in Knee Osteoarthritis: Results from the PROP OA Randomized Trial

newsknee osteoarthritispain management

Compartment-Specific Knee Bracing Improves Outcomes in Knee Osteoarthritis: Results from the PROP OA Randomized Trial

By MedXY|Feb 23, 2026

The PROP OA trial demonstrates that adding compartment-specific knee bracing and adherence support to standard exercise and advice significantly improves pain and function in patients with knee osteoarthritis, offering a safe and effective

Combination Therapy Fails to Outperform Ibuprofen Alone for Pediatric Musculoskeletal Pain: Evidence from Two Randomized Controlled Trials

Emergency Medicineemergency medicineibuprofen

Combination Therapy Fails to Outperform Ibuprofen Alone for Pediatric Musculoskeletal Pain: Evidence from Two Randomized Controlled Trials

By MedXY|Jan 25, 2026

New clinical trials reveal that adding acetaminophen or hydromorphone to ibuprofen provides no additional pain relief for children with acute musculoskeletal injuries, while the addition of opioids significantly increases the risk of advers

Combined Fascial Plane Blocks Fail to Superiorize Paravertebral Block in Mastectomy: Results from a 1,507-Patient Cluster-Randomized Trial

AnesthesiologyGây tê khu vựcOpioid Stewardship

Combined Fascial Plane Blocks Fail to Superiorize Paravertebral Block in Mastectomy: Results from a 1,507-Patient Cluster-Randomized Trial

By MedXY|Jan 19, 2026

A large-scale cluster-randomized trial involving 1,507 patients demonstrated that adding PECS I blocks to paravertebral or serratus anterior plane blocks does not reduce postoperative opioid use or improve recovery compared to paravertebral

Graded Sensorimotor Retraining for Chronic Low Back Pain: Clinical Efficacy and the Search for Treatment Responders

Neurologychronic low back painclinical trial

Graded Sensorimotor Retraining for Chronic Low Back Pain: Clinical Efficacy and the Search for Treatment Responders

By MedXY|Jan 16, 2026

The RESOLVE trial demonstrates that graded sensorimotor retraining provides modest pain relief for chronic low back pain. A secondary analysis reveals that these benefits are consistent across most patient subgroups, suggesting that the int

Impact of Clinical Guidelines: Assessing the Decline in ICU Delirium and Pain Prevalence Over a Decade

Anesthesiologypain managementpatient outcomes

Impact of Clinical Guidelines: Assessing the Decline in ICU Delirium and Pain Prevalence Over a Decade

By MedXY|Dec 26, 2025

A comprehensive meta-analysis of 226 publications involving 183,285 patients reveals a significant reduction in ICU delirium and pain following the 2013 PAD guidelines, though prevalence remains high at approximately 36% and 44%, respective

Continuous Erector Spinae Plane Block Proven Non-Inferior to Opioids for VATS Pain While Enhancing Recovery Quality

AnesthesiologyGây tê khu vựcpain management

Continuous Erector Spinae Plane Block Proven Non-Inferior to Opioids for VATS Pain While Enhancing Recovery Quality

By MedXY|Dec 21, 2025

A randomized trial demonstrates that continuous erector spinae plane block provides comparable analgesia to opioid regimens after VATS, while significantly improving patient recovery scores and reducing postoperative complications.

Misoprostol Offers Little Benefit for Routine IUD Placement, Except in Select Cases

newspain management

Misoprostol Offers Little Benefit for Routine IUD Placement, Except in Select Cases

By MedXY|Dec 17, 2025

Evidence shows misoprostol rarely improves routine IUD placement outcomes but may benefit women with prior failed attempts.

Progestagens Show Promise for Pain Relief in Endometriosis, With Nuanced Efficacy Across Comparators

newsendometriosishormonal therapy

Progestagens Show Promise for Pain Relief in Endometriosis, With Nuanced Efficacy Across Comparators

By MedXY|Dec 17, 2025

Oral progestagens likely reduce overall pain and dysmenorrhoea in endometriosis, but comparative benefits over other hormonal treatments remain uncertain.

Online Unsupervised Tai Chi Intervention for Knee Osteoarthritis: Insights from the RETREAT Randomized Clinical Trial and Systematic Reviews

Clinical Updatesknee osteoarthritispain management

Online Unsupervised Tai Chi Intervention for Knee Osteoarthritis: Insights from the RETREAT Randomized Clinical Trial and Systematic Reviews

By MedXY|Oct 29, 2025

This review synthesizes evidence from the RETREAT RCT and past systematic reviews, highlighting that an unsupervised online Tai Chi program significantly improves knee pain and function in knee osteoarthritis, providing a scalable, accessib

Evaluating Pilates for Knee Osteoarthritis: Efficacy, Safety, and Clinical Insights from Recent Meta-Analysis

newsknee osteoarthritisMeta-Analysis

Evaluating Pilates for Knee Osteoarthritis: Efficacy, Safety, and Clinical Insights from Recent Meta-Analysis

By MedXY|Oct 11, 2025

A systematic review and meta-analysis of RCTs indicates Pilates may improve pain and function in knee osteoarthritis patients, though evidence quality is low and safety data insufficient. Caution is warranted in interpreting results, highli

Dexmedetomidine for Analgesia in Nonintubated Patients With Traumatic Rib Fractures: A Randomized Clinical Trial Analysis

Anesthesiologydexmedetomidineintensive care

Dexmedetomidine for Analgesia in Nonintubated Patients With Traumatic Rib Fractures: A Randomized Clinical Trial Analysis

By MedXY|Oct 10, 2025

This trial found that adjunctive dexmedetomidine did not reduce opioid use, pain scores, or pulmonary complications in nonintubated ICU patients with traumatic rib fractures, challenging its routine analgesic use in this setting.

Personalized Anti-Inflammatory Diet Modulates Gut Microbiome and Metabolome to Alleviate Osteoarthritis Pain

Clinical UpdatesAnti-inflammatory Dietgut microbiome

Personalized Anti-Inflammatory Diet Modulates Gut Microbiome and Metabolome to Alleviate Osteoarthritis Pain

By MedXY|Oct 8, 2025

A 4-week anti-inflammatory dietary intervention in knee osteoarthritis patients led to targeted shifts in gut microbiota and metabolite profiles associated with significant pain reduction, highlighting the potential of microbiome-informed n

Intercostal Nerve Block: A Viable Alternative to Thoracic Epidural for Pain Control in Lung Surgery

Anesthesiologypain managementThoracic surgery

Intercostal Nerve Block: A Viable Alternative to Thoracic Epidural for Pain Control in Lung Surgery

By MedXY|Oct 7, 2025

This randomized trial demonstrates that single-shot intercostal nerve block offers noninferior pain relief compared to thoracic epidural analgesia after thoracoscopic lung resection, with benefits in opioid reduction, mobility, and shorter

Live Music Therapy in Advanced Cancer: Efficacy in Pain and Symptom Relief Confirmed by MSPD Pilot Study and Meta-Analysis

Clinical Updatesadvanced cancermusic therapy

Live Music Therapy in Advanced Cancer: Efficacy in Pain and Symptom Relief Confirmed by MSPD Pilot Study and Meta-Analysis

By MedXY|Oct 4, 2025

A single session of live music therapy significantly reduced pain, fatigue, and anxiety in advanced cancer patients, with high patient satisfaction. These findings align with meta-analytic evidence supporting music therapy’s benefits

Expanding Access to Chronic Pain Care: Telehealth and Online CBT-Based Interventions Show Promise

Clinical UpdatesCBTchronic pain

Expanding Access to Chronic Pain Care: Telehealth and Online CBT-Based Interventions Show Promise

By MedXY|Sep 30, 2025

Remote CBT-based interventions, delivered by telehealth or online modules, offer modest but significant improvements in pain and function for individuals with high-impact chronic pain, enhancing access to evidence-based care.

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