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This study identifies novel proteomic and metabolomic biomarkers linked to cardiac dysfunction and remodeling in breast cancer patients treated with cardiotoxic therapies, revealing potential pathways for early detection and intervention.
This study identifies glycine and specific lipid cholesterol proportions as metabolomic markers causally linked to lacunar stroke subtypes, enhancing understanding of cerebral small vessel disease pathogenesis and potential biomarkers.
This study reveals how cardiac resynchronization therapy (CRT) improves left ventricular function in heart failure patients and modulates systemic metabolomic profiles, highlighting differences between ischemic and nonischemic cardiomyopath
A large European cohort study identifies six circulating metabolites significantly associated with future stroke risk, highlighting their potential in improving early stroke risk prediction beyond classic risk factors.
This study reveals unique fatty acid and oxylipin metabolic signatures that differentiate isolated postcapillary pulmonary hypertension from combined pre- and postcapillary PH, highlighting potential biomarkers and therapeutic targets.
Central obesity in women and high overall body fat in men are linked to increased odds of dry eye disease, with distinct metabolic pathways implicated, based on a retrospective analysis of over 480,000 UK Biobank participants.
Liver transplantation facilitates early neurocognitive recovery in end-stage liver disease patients by restoring cortical network activities, with S-methyl-5′-thioadenosine playing a pivotal neuroprotective role through modulating neu
Distinct gut microbial profiles but shared metabolomic markers, especially fecal acetate, predict response and survival with combination immunotherapy in metabolic dysfunction-associated and viral hepatitis-related hepatocellular carcinoma.
A metabolomic clock based on plasma metabolites accurately estimated chronological age (r=0.92) and was associated with mortality, frailty, and cognitive impairment across two European cohorts.
This analysis reviews a pilot study evaluating high-dose levothyroxine treatment in adult RTHα patients, demonstrating safety, improved quality of life, and distinct metabolic alterations over three years.
Post-hoc metabolomic and lipidomic analyses from two phase 2 trials suggest retatrutide favorably remodels metabolic pathways linked to fatty acid oxidation, insulin resistance, and triglyceride composition in obesity, with and without type
A landmark study reveals that exercise-induced multi-organ physiologic deficits strongly predict incident heart failure with preserved ejection fraction (HFpEF). Using invasive cardiopulmonary testing, metabolomics, and genomics across over
A massive UK Biobank study demonstrates that combining serum metabolomics with polygenic risk scores and clinical data significantly improves the prediction of incident atrial fibrillation, identifying key metabolic markers like linoleic ac
A large-scale UK Biobank study demonstrates that combining NMR metabolomics, polygenic risk scores, and clinical biomarkers with SCORE2 significantly enhances cardiovascular risk prediction, potentially doubling the number of prevented even
A large-scale UK Biobank study demonstrates that combining NMR metabolomics and polygenic risk scores with the SCORE2 framework significantly improves cardiovascular risk discrimination, potentially doubling the number of preventable events
A groundbreaking study identifies N-palmitoyl glutamine (NPG) as a key molecular transducer of cardiorespiratory fitness. NPG correlates with VO2max, increases with exercise training, predicts lower mortality, and directly enhances mitochon
Altered gut microbiota composition and metabolism exacerbate cirrhotic portal hypertension, highlighting potential microbiome-targeted therapies to mitigate disease progression.
Recent research reveals distinct gut microbial and metabolic profiles linked to ADHD symptoms, highlighting short-chain fatty acid deficiency as a key mechanism driving hyperactivity and inattention.
A 4-week anti-inflammatory dietary intervention in knee osteoarthritis patients led to targeted shifts in gut microbiota and metabolite profiles associated with significant pain reduction, highlighting the potential of microbiome-informed n
This review synthesizes the latest 5-year evidence on dihydroberberine, highlighting improved bioavailability over berberine, mechanistic insights from metabolic and network pharmacology studies, and its promising clinical applications in m