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SOFA-2 Recalibrated: Global Development and Validation of an Updated Organ Dysfunction Score in >3.3 Million ICU Admissions

SOFA-2 updates the 30-year-old SOFA score using data from >3.3 million ICU admissions across diverse settings. The revised tool modestly improves ICU mortality discrimination (AUROC 0.79 vs 0.77) and incorporates contemporary organ support,

Section: Critical CareNov 8, 2025

Targeting Capillary Refill Time in Early Septic Shock Reduced Duration of Organ Support: Key Findings from ANDROMEDA‑SHOCK‑2

ANDROMEDA‑SHOCK‑2 randomized 1,501 patients with early septic shock to a personalized CRT‑guided hemodynamic protocol versus usual care. A hierarchical composite outcome favored the CRT strategy (win ratio 1.16; 95% CI 1.02–1.33; P = .04),

critical care

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SOFA-2 Recalibrated: Global Development and Validation of an Updated Organ Dysfunction Score in >3.3 Million ICU Admissions

Targeting Capillary Refill Time in Early Septic Shock Reduced Duration of Organ Support: Key Findings from ANDROMEDA‑SHOCK‑2

Resistance Training in the ICU Improves Muscle, Function, and Survival — HMB Adds Only Modest Benefit

Sodium Bicarbonate in Severe Metabolic Acidemia with AKI: No Survival Benefit but Less Dialysis — Insights from BICARICU-2

Adjunctive Terlipressin in Refractory Septic Shock: Lowers High-Dose Catecholamine Need at 6 Hours but No Mortality Benefit

Renal Contrast‑Enhanced Ultrasound Is Reproducible in Stable Critically Ill Patients — mTT Is the Most Robust Metric

Rescue Noninvasive Ventilation After Extubation: High Failure but No Clear Increase in Hospital Mortality — A Post‑hoc RINO Trial Analysis

Continuous Intravenous Sedation Produces Novel EEG ‘Ups’ in Early Acute Hypoxemic Respiratory Failure — Implications for Monitoring and Outcomes

Noninferiority of Deferring Early Arterial Catheterization in Shock Management: Insights from a Multicenter RCT

Optimizing Critical Care Outcomes: The Pivotal Role of Rehabilitation and Physiotherapy

Innovative Respiratory Gas Delivery Device Significantly Extends Survival Time in Simulated Critical Avalanche Burial

Exertional Heat Stroke: Critical Insights for Emergency Physicians

Proportional-Assist Ventilation vs. Pressure-Support Ventilation: Implications for Liberation from Mechanical Ventilation

Proportional-Assist Ventilation and Pressure-Support Ventilation: Comparative Impact on Mechanical Ventilation Duration in Critical Care

Long-Term Functional Recovery and Survival after VA-ECMO: Insights from a 26-Center Prospective Cohort Study

Normosol-R versus Lactated Ringers in Critical Care: Evaluating Balanced Crystalloids for Optimal Patient Outcomes

UK-ROX Trial: Conservative Oxygen Strategy in Mechanically Ventilated ICU Patients — No 90‑Day Survival Benefit