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Melatonin Does Not Prevent Delirium in the Intensive Care Unit: Insights from a Comprehensive Meta-Analysis

MedXY Editorial Team•Dec 28, 2025•Critical Care
critical caredeliriummelatoninmeta-analysis

Highlights

– A comprehensive meta-analysis of 13 randomized controlled trials finds no benefit for melatonin in delirium prevention.
– Primary analysis restricted to low-to-moderate risk of bias studies confirms no significant reduction in delirium incidence (RR 0.89).
– Melatonin administration does not influence mortality rates among critically ill patients, suggesting a limited role for this hormone in acute recovery.

Introduction: The Burden of Delirium in Critical Care

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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

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