Pregnancies Following Peri-Partum Cardiomyopathy: Insights from the ESC EuroObservational Research Programme

Study Background and Disease Burden

Peri-partum cardiomyopathy (PPCM) is a rare but serious cardiac condition that manifests towards the end of pregnancy or in the months following delivery. It is characterized by left ventricular systolic dysfunction leading to heart failure. Women diagnosed with PPCM face a challenging prognosis in subsequent pregnancies (SSPs), as the risk of heart failure progression or maternal mortality remains a significant concern. Historically, clinical guidance has often been cautious or even contraindicated regarding SSPs in women recovering from PPCM, especially with persistent left ventricular impairment. However, existing data are limited, often retrospective, and not representative of diverse ethnic or sociodemographic groups. This gaps in knowledge constrains evidence-based counseling and management strategies for affected women desiring future pregnancies.

Study Design