Parenteral vs Oral Glucocorticoids in Early Rheumatoid Arthritis: Impact on Steroid Discontinuation and Therapy Escalation at One Year
rheumatoid arthritisparenteral administrationsteroid discontinuationearly arthritis therapyglucocorticoids
Highlight
- Parenteral glucocorticoid administration in early rheumatoid arthritis (ERA) is associated with significantly lower odds of persistent steroid use at 12 months compared to oral administration.
- Rates of escalation to advanced therapies at one year do not significantly differ between parenteral and oral glucocorticoid users.
- Most patients in early rheumatoid arthritis cohorts do not receive glucocorticoids initially; among those treated, oral administration is more common than parenteral.
- Use of parenteral glucocorticoids may facilitate earlier steroid discontinuation, potentially reducing long-term glucocorticoid-related adverse effects.
Study Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.