Lipoprotein(a) and Atherosclerotic Cardiovascular Disease Risk Across the Adult Lifespan: Insights from a Large Population Study

Highlight

• High lipoprotein(a) [Lp(a)] levels are associated with increased risk of atherosclerotic cardiovascular disease (ASCVD) equally across all adult age groups, including those aged 70 to 100 years.
• The absolute incidence of ASCVD events associated with elevated Lp(a) increases substantially with advancing age, notably highest in adults aged 80 years and older.
• These associations are consistent in both men and women, although men exhibit somewhat higher absolute risk increases.
• The study provides robust evidence supporting Lp(a) measurement and potential future therapeutic targeting across a wide age spectrum for primary prevention of ASCVD.

Study Background