Serum neurofilament light chain (sNfL) is significantly associated with major vascular events (MVEs) in patients with atrial fibrillation (AF), independent of traditional risk factors.
The SWISS-AF cohort study reveals that every doubling of sNfL concentration corresponds to a 35% increase in the risk of MVEs.
Higher sNfL levels are linked to nonfatal stroke, cardiovascular death, heart failure-related hospitalization, and all-cause mortality, though not to myocardial infarction.
sNfL represents a novel, multi-organ prognostic tool that may refine risk stratification in the complex AF patient population.
Background
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