Universal Aspirin Dispensation for Prevention of Preeclampsia in High-Risk Pregnancies: Evidence Synthesis and Clinical Implications
Highlights
- Universal aspirin administration (162 mg daily) starting early in pregnancy reduces incidence and delays onset of preeclampsia with severe features in high-risk populations.
- Implementation of direct aspirin dispensation during prenatal visits leads to high adherence (~80%) and favorable maternal and neonatal outcomes without increased bleeding or abruption risk.
- Early aspirin initiation (before 12 weeks’ gestation) further improves hypertensive and neonatal outcomes beyond standard practice.
- Advanced first-trimester screening algorithms incorporating biomarkers (e.g., PlGF) enhance risk identification but may benefit from complementing universal aspirin strategies in high-prevalence settings.
Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.