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Comparative 1-Year Outcomes of Semaglutide, Tirzepatide, and Sleeve Gastrectomy in Obese Adults with Type 2 Diabetes: Insights from Real-World Data

A retrospective cohort study evaluating 1-year weight loss, glycaemic control, and safety outcomes among adults with obesity and type 2 diabetes treated with semaglutide, tirzepatide, or sleeve gastrectomy, highlighting higher efficacy with

Section: Diabetes & EndocrinologyJun 20, 2026

Early 15% Weight Loss After Type 2 Diabetes Diagnosis Linked to Lower Complication Risk

In a large U.K. cohort, losing at least 15% of body weight within 2 years of type 2 diabetes diagnosis was linked to lower risks of heart, kidney, and eye complications, along with better glucose and blood pressure control.

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Comparative 1-Year Outcomes of Semaglutide, Tirzepatide, and Sleeve Gastrectomy in Obese Adults with Type 2 Diabetes: Insights from Real-World Data

Early 15% Weight Loss After Type 2 Diabetes Diagnosis Linked to Lower Complication Risk

Two-Year SURPASS-EARLY Findings Show Tirzepatide Outperforms Intensified Conventional Care in Early Type 2 Diabetes

Semaglutide Improves Insulin Sensitivity in Patients With Schizophrenia, Prediabetes, and Obesity Treated With Second-Generation Antipsychotics: Findings From the HISTORI Trial

Managing Obesity as a Chronic Disease: The 2026 WHO Guidelines on GLP-1 Therapies

Behavioral Diet Therapy Achieves Superior Postprandial Glycemic Control Over Gastric Bypass Despite Equivalent Weight Loss

Tailored Weight Loss Interventions in Serious Mental Illness: A Comprehensive Review of Evidence and Clinical Implications

Tailored Weight Loss Interventions for Veterans with Serious Mental Illness: Efficacy and Implementation Insights from Recent RCT Evidence

Aggressive Risk Factor Management Improves 12‑Month Ablation Success: Insights from the ARREST‑AF Randomized Trial

Tirzepatide Produces Large Real‑World Weight Loss in Women with PCOS

Weekly Amylin Agonist Eloralintide Produces 10–21% Weight Loss at 48 Weeks in Phase 2 Trial

Obesity Interventions and Male Fertility: Unraveling the Effects of Weight Loss on Reproductive Health

Tirzepatide Influences Muscle Composition Favorably Amid Weight Loss in Type 2 Diabetes: Insights from SURPASS-3 MRI Substudy

From Plate to Progress: Five Scientifically Proven Diets to Help Manage Obesity Effectively

Optimizing Metabolic and Physical Health in Obese Older Adults: Impact of Exercise Modalities on Insulin Secretion, CNTF, and IGF-1 During Weight Loss

Oral Semaglutide Demonstrates Significant Weight Loss Efficacy in East Asian Adults with Overweight or Obesity: Insights from the OASIS 2 Trial

Once-Weekly Semaglutide 2.4 mg for Obesity Management in Asian Adults: Efficacy, Safety, and Policy Insights from the STEP 11 Trial

Advancing Obesity Management: Once-Monthly Maridebart Cafraglutide Demonstrates Significant Weight Loss Efficacy

CagriSema: A Breakthrough Combination Therapy for Weight Loss in Adults with Overweight or Obesity