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Intravenous Magnesium Sulfate for Acute Nontraumatic Headache in the Emergency Department

Intravenous Magnesium Sulfate for Acute Nontraumatic Headache in the Emergency Department

Intravenous magnesium sulfate added to paracetamol increased early headache-treatment success in the emergency department, but the pain relief was modest and below usual clinical importance thresholds. It also reduced rescue analgesia needs

Section: Emergency MedicineMay 22, 2026

ABRUPT2 Trial: 5% Albumin Reduced Fluid Requirements in Major Burn Resuscitation

ABRUPT2 Trial: 5% Albumin Reduced Fluid Requirements in Major Burn Resuscitation

ABRUPT2 found that adding 5% albumin to lactated Ringer’s significantly reduced fluid needs in the first 48 hours after major burns, without clear differences in mortality, kidney injury, or healing time.

Section: Critical CareMay 20, 2026

Produce Prescription for Diabetes Falls Short in Improving Health Outcomes

Produce Prescription for Diabetes Falls Short in Improving Health Outcomes

A randomized trial found that a $80 monthly produce prescription did not significantly improve HbA1c levels or reduce healthcare utilization in diabetic patients at risk of food insecurity.

Section: Diabetes & EndocrinologyApr 21, 2026

Tailored Digital Emotion Regulation Improves Mental Health in Adults With Congenital Heart Disease: Results of a National Randomized Trial

Tailored Digital Emotion Regulation Improves Mental Health in Adults With Congenital Heart Disease: Results of a National Randomized Trial

A 3‑arm randomized trial in 524 adults with congenital heart disease found a 4‑week tailored digital emotion‑regulation program produced moderate improvements in emotion regulation and multiple psychosocial outcomes versus usual care; a gen

Section: CardiologyDec 15, 2025

Supplemental Donor Human Milk Did Not Speed Full Enteral Feeding in Moderate–Late Preterm Infants: Results From a Multisite Randomized Trial

Supplemental Donor Human Milk Did Not Speed Full Enteral Feeding in Moderate–Late Preterm Infants: Results From a Multisite Randomized Trial

In a blinded multisite RCT of 201 moderate–late preterm infants, short-term supplementation with pasteurized donor human milk versus term formula did not shorten time to full enteral feeds; donor milk was associated with slower regain of bi

Section: newsDec 14, 2025

Conservative vs Liberal Post‑Oxygenator Targets on VA‑ECMO: Feasibility Concerns and No Early Biomarker Benefit in a Pilot RCT

Conservative vs Liberal Post‑Oxygenator Targets on VA‑ECMO: Feasibility Concerns and No Early Biomarker Benefit in a Pilot RCT

A pilot multicenter RCT comparing conservative vs liberal post-oxygenator oxygen targets during VA-ECMO for cardiogenic shock found the conservative approach difficult to maintain (target achieved 33% of time) and no difference in biomarker

Section: CardiologyDec 12, 2025

Home-Based Prehabilitation Did Not Reduce Disability or Complications in Older Adults with Frailty: Results of a Pragmatic Multicenter RCT

Home-Based Prehabilitation Did Not Reduce Disability or Complications in Older Adults with Frailty: Results of a Pragmatic Multicenter RCT

A pragmatic multicenter randomized trial found that coach-supported, home-based multimodal prehabilitation before elective noncardiac surgery did not reduce 30-day postoperative disability or in-hospital complications in older adults with f

Section: AnesthesiologyDec 9, 2025

Morphine Does Not Relieve Chronic Breathlessness: The MABEL Trial Finds No Benefit and Signals More Harms

Morphine Does Not Relieve Chronic Breathlessness: The MABEL Trial Finds No Benefit and Signals More Harms

A UK multicentre randomized placebo‑controlled trial (MABEL) showed no improvement in worst breathlessness with low‑dose oral morphine versus placebo at 28 days, with more adverse events and withdrawals in the morphine arm.

Section: newsNov 24, 2025

Therapist-Guided e‑Health Cuts Fear of Cancer Recurrence in Colorectal Survivors: A Randomized Trial Shows Clinically Meaningful Benefits

Therapist-Guided e‑Health Cuts Fear of Cancer Recurrence in Colorectal Survivors: A Randomized Trial Shows Clinically Meaningful Benefits

A Danish RCT of TG‑iConquerFear, a 10‑week therapist‑guided online program for colorectal cancer survivors with clinical fear of cancer recurrence (FCR), reduced FCR scores substantially compared with augmented self‑help at 3 months; the be

Section: AINov 20, 2025

Remote Cognitive Training, Structured Rehabilitation and tDCS Failed to Improve Self‑Reported Cognitive Symptoms in Long COVID: Results from a 5‑Arm Phase 2 Randomized Trial

Remote Cognitive Training, Structured Rehabilitation and tDCS Failed to Improve Self‑Reported Cognitive Symptoms in Long COVID: Results from a 5‑Arm Phase 2 Randomized Trial

A multicenter phase 2 randomized trial found no differential benefit of adaptive computerized cognitive training, structured cognitive rehabilitation, or transcranial direct current stimulation (tDCS) versus active comparators for self‑repo

Section: Infectious DiseasesNov 18, 2025

Genomically Matched Therapy Improves Response and PFS Across Advanced Solid Tumors: Phase 2 ROME Trial

Genomically Matched Therapy Improves Response and PFS Across Advanced Solid Tumors: Phase 2 ROME Trial

The randomized phase 2 ROME trial showed that genomically matched, MTB-guided therapy increased overall response rate and progression-free survival versus standard care in heavily pretreated advanced solid tumors, supporting a tumor-agnosti

Section: newsNov 12, 2025

Atosiban Did Not Improve Neonatal Outcomes for Threatened Preterm Birth at 30–34 Weeks: Results from the Multicentre APOSTEL 8 Trial

Atosiban Did Not Improve Neonatal Outcomes for Threatened Preterm Birth at 30–34 Weeks: Results from the Multicentre APOSTEL 8 Trial

In the APOSTEL 8 randomized trial, intravenous atosiban did not reduce a composite of perinatal mortality and severe neonatal morbidity versus placebo for threatened preterm birth at 30+0–33+6 weeks.

Section: newsDec 16, 2025

Metformin Does Not Improve Walking Distance in Peripheral Artery Disease: Results from the PERMET Randomized Trial

Metformin Does Not Improve Walking Distance in Peripheral Artery Disease: Results from the PERMET Randomized Trial

The PERMET randomized, double-blind trial found that 6 months of metformin did not improve 6-minute walk distance or other functional endpoints in people with lower extremity peripheral artery disease (PAD) without diabetes.

Section: CardiologyNov 9, 2025

Rituximab Markedly Reduces Relapse in Adult Relapsing Nephrotic Syndrome: Randomized Trial Data from Japan

Rituximab Markedly Reduces Relapse in Adult Relapsing Nephrotic Syndrome: Randomized Trial Data from Japan

A multicenter randomized trial in Japan found that rituximab significantly increased 49‑week relapse‑free survival versus placebo in adults with frequently relapsing or steroid‑dependent nephrotic syndrome, though infusion reactions were co

Section: NephrologyNov 7, 2025

Physical Therapy for Degenerative Meniscal Tear: No Added Benefit Over Home Exercise Alone in Knee Pain Management

Physical Therapy for Degenerative Meniscal Tear: No Added Benefit Over Home Exercise Alone in Knee Pain Management

A randomized trial shows that physical therapy and text message reminders do not significantly improve knee pain outcomes beyond a simple home exercise program in patients aged 45-85 with degenerative meniscal tears.

Section: Internal MedicineOct 31, 2025

Comparative Efficacy and Tolerability of Seven Antipsychotics in Acute Schizophrenia: Insights from a Large Multicenter Randomized Trial

Comparative Efficacy and Tolerability of Seven Antipsychotics in Acute Schizophrenia: Insights from a Large Multicenter Randomized Trial

A multicenter randomized trial comparing seven antipsychotics in acute schizophrenia shows olanzapine and risperidone outperform several agents in efficacy but differ markedly in side effects, clarifying treatment choices.

Section: newsOct 29, 2025

Evaluating Cardiovascular-Focused Messaging to Enhance Influenza Vaccination Uptake in Diverse U.S. Populations

Evaluating Cardiovascular-Focused Messaging to Enhance Influenza Vaccination Uptake in Diverse U.S. Populations

A large randomized trial in the U.S. found no significant improvement in influenza vaccination rates with cardiovascular-focused messaging compared to usual care, despite prior positive findings in Denmark.

Section: CardiologyOct 4, 2025

Evaluating Low-Dose Aspirin for Postpartum Venous Thromboembolism Prevention: Insights from the Pilot PARTUM Trial

Evaluating Low-Dose Aspirin for Postpartum Venous Thromboembolism Prevention: Insights from the Pilot PARTUM Trial

The pilot PARTUM trial demonstrates the feasibility of a large-scale multi-national randomized study assessing low-dose aspirin versus placebo for postpartum venous thromboembolism prevention in moderate-risk individuals, supporting further

Section: Clinical UpdatesOct 9, 2025

Aspirin for Delaying Preterm Birth in High-Risk Preterm Pre-eclampsia Pregnancies: Insights from a Multicenter Randomized Trial in Asia

Aspirin for Delaying Preterm Birth in High-Risk Preterm Pre-eclampsia Pregnancies: Insights from a Multicenter Randomized Trial in Asia

Early low-dose aspirin reduces early preterm birth risk and delays timing of delivery in women at high risk for preterm pre-eclampsia, with significant benefits in iatrogenic preterm births and small-for-gestational-age pregnancies.

Section: Clinical UpdatesOct 9, 2025

Unlocking Better Sleep: How Daily Walnut Consumption Enhances Melatonin Metabolism and Sleep Quality in Young Adults

Unlocking Better Sleep: How Daily Walnut Consumption Enhances Melatonin Metabolism and Sleep Quality in Young Adults

A randomized crossover trial shows that daily intake of 40 g walnuts increases urinary 6-sulfatoxymelatonin, reduces sleep latency, and improves global sleep quality in young adults, highlighting walnuts’ potential as a natural sleep aid.

Section: Family Medicine & NutritionOct 8, 2025