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Acute Effects of Cannabis Inhalation on Cardiac Ectopy, Physical Activity, Sleep, and Glucose: A Synthesis of Clinical Evidence and Mechanistic Insights
Cardiologyrandomized trialcardiac ectopy

Acute Effects of Cannabis Inhalation on Cardiac Ectopy, Physical Activity, Sleep, and Glucose: A Synthesis of Clinical Evidence and Mechanistic Insights

By MedXY|Aug 15, 2026

This review integrates recent randomized trial data with observational studies to clarify cannabis inhalation’s acute impact on cardiac ectopy, physical activity, sleep, and glucose, highlighting complex arrhythmia associations and cl

Levothyroxine in Pregnancy for Subclinical Hypothyroidism or Hypothyroxinemia: No Benefit on Child IQ
Diabetes & Endocrinologyrandomized trial
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Contact usAbout usPrivacy PolicyMedXY story
Pregnancy

Levothyroxine in Pregnancy for Subclinical Hypothyroidism or Hypothyroxinemia: No Benefit on Child IQ

By MedXY|Aug 18, 2026

A randomized trial found that levothyroxine treatment for subclinical hypothyroidism or hypothyroxinemia starting between 8 and 20 weeks of gestation did not improve IQ scores in children at age 5 years compared with placebo.

Enhancing Preventive Screening Uptake: EHR Portal Messages Boost Mammography Rates
Diabetes & EndocrinologyElectronic Health RecordsMammography Screening

Enhancing Preventive Screening Uptake: EHR Portal Messages Boost Mammography Rates

By MedXY|Jul 2, 2026

Iterative redesign of electronic health record (EHR) portal reminders significantly improved mammography screening adherence in an outpatient setting, demonstrating the value of concise messages with scheduling links, while retinal and HbA1

High-Dose Vitamin C After Cardiac Arrest: Promise Meets a Negative Signal in VITaCCA
Cardiologycardiac arrestcritical care

High-Dose Vitamin C After Cardiac Arrest: Promise Meets a Negative Signal in VITaCCA

By MedXY|Jun 19, 2026

In a multicenter phase 2 trial, early intravenous vitamin C did not improve post-cardiac arrest organ dysfunction and the 10 g dose was associated with worse outcomes, including renal, cardiac, and neurologic signals.

Diabetes & Endocrinologydietetic guidanceHbA1c

Time-Restricted Eating vs Dietetic Guidance for Glycaemic Outcomes in Adults at Risk of Type 2 Diabetes

By MedXY|Jun 17, 2026

Time-restricted eating performed similarly to individualized dietetic guidance for short-term HbA1c change in adults at risk of type 2 diabetes, but non-inferiority was not confirmed at 12 months. Benefits were small, and adverse events wer

Role of Atrial Pacing Support in Cardiac Resynchronization Therapy: A Noninferiority Randomized Trial
Cardiologyatrial pacingCRT-D

Role of Atrial Pacing Support in Cardiac Resynchronization Therapy: A Noninferiority Randomized Trial

By MedXY|Jun 10, 2026

A randomized trial found that a two-lead CRT-D system without atrial pacing was noninferior to standard three-lead CRT-D in selected heart failure patients, with fewer atrial lead-related complications.

Acetazolamide Fails to Improve Gait in Idiopathic Normal Pressure Hydrocephalus: Swedish DRAIN Trial
Internal Medicineacetazolamidegait disorder

Acetazolamide Fails to Improve Gait in Idiopathic Normal Pressure Hydrocephalus: Swedish DRAIN Trial

By MedXY|Jun 5, 2026

In a Swedish randomized trial, low-dose acetazolamide did not improve gait in patients with idiopathic normal pressure hydrocephalus and caused more side effects than placebo, arguing against routine use as medical therapy.

Enteral vs IV Magnesium Replacement in Critically Ill Patients: A Randomized Noninferiority Trial
Critical Carecritical careenteral therapy

Enteral vs IV Magnesium Replacement in Critically Ill Patients: A Randomized Noninferiority Trial

By MedXY|Jun 5, 2026

A randomized ICU trial found oral/enteral magnesium was not proven noninferior to IV replacement for correcting mild-to-moderate hypomagnesemia, but it lowered urinary magnesium loss, cost, waste, carbon emissions, and IV fluid use.

Intravenous Magnesium Sulfate for Acute Nontraumatic Headache in the Emergency Department
Emergency Medicineacute nontraumatic headacheemergency department

Intravenous Magnesium Sulfate for Acute Nontraumatic Headache in the Emergency Department

By MedXY|May 22, 2026

Intravenous magnesium sulfate added to paracetamol increased early headache-treatment success in the emergency department, but the pain relief was modest and below usual clinical importance thresholds. It also reduced rescue analgesia needs

ABRUPT2 Trial: 5% Albumin Reduced Fluid Requirements in Major Burn Resuscitation
Critical CareAlbuminburn resuscitation

ABRUPT2 Trial: 5% Albumin Reduced Fluid Requirements in Major Burn Resuscitation

By MedXY|May 20, 2026

ABRUPT2 found that adding 5% albumin to lactated Ringer’s significantly reduced fluid needs in the first 48 hours after major burns, without clear differences in mortality, kidney injury, or healing time.

Produce Prescription for Diabetes Falls Short in Improving Health Outcomes
Diabetes & EndocrinologydiabetesProduce Prescription

Produce Prescription for Diabetes Falls Short in Improving Health Outcomes

By MedXY|Apr 21, 2026

A randomized trial found that a $80 monthly produce prescription did not significantly improve HbA1c levels or reduce healthcare utilization in diabetic patients at risk of food insecurity.

Tailored Digital Emotion Regulation Improves Mental Health in Adults With Congenital Heart Disease: Results of a National Randomized Trial
Cardiologycongenital heart diseaseEmotion regulation

Tailored Digital Emotion Regulation Improves Mental Health in Adults With Congenital Heart Disease: Results of a National Randomized Trial

By MedXY|Dec 14, 2025

A 3‑arm randomized trial in 524 adults with congenital heart disease found a 4‑week tailored digital emotion‑regulation program produced moderate improvements in emotion regulation and multiple psychosocial outcomes versus usual care; a gen

Supplemental Donor Human Milk Did Not Speed Full Enteral Feeding in Moderate–Late Preterm Infants: Results From a Multisite Randomized Trial
newsdonor milkenteral feeding

Supplemental Donor Human Milk Did Not Speed Full Enteral Feeding in Moderate–Late Preterm Infants: Results From a Multisite Randomized Trial

By MedXY|Dec 14, 2025

In a blinded multisite RCT of 201 moderate–late preterm infants, short-term supplementation with pasteurized donor human milk versus term formula did not shorten time to full enteral feeds; donor milk was associated with slower regain of bi

Conservative vs Liberal Post‑Oxygenator Targets on VA‑ECMO: Feasibility Concerns and No Early Biomarker Benefit in a Pilot RCT
Cardiologycardiogenic shockoxygenation

Conservative vs Liberal Post‑Oxygenator Targets on VA‑ECMO: Feasibility Concerns and No Early Biomarker Benefit in a Pilot RCT

By MedXY|Dec 12, 2025

A pilot multicenter RCT comparing conservative vs liberal post-oxygenator oxygen targets during VA-ECMO for cardiogenic shock found the conservative approach difficult to maintain (target achieved 33% of time) and no difference in biomarker

Home-Based Prehabilitation Did Not Reduce Disability or Complications in Older Adults with Frailty: Results of a Pragmatic Multicenter RCT
AnesthesiologyFrailtyperioperative care

Home-Based Prehabilitation Did Not Reduce Disability or Complications in Older Adults with Frailty: Results of a Pragmatic Multicenter RCT

By MedXY|Dec 9, 2025

A pragmatic multicenter randomized trial found that coach-supported, home-based multimodal prehabilitation before elective noncardiac surgery did not reduce 30-day postoperative disability or in-hospital complications in older adults with f

Morphine Does Not Relieve Chronic Breathlessness: The MABEL Trial Finds No Benefit and Signals More Harms
newsmorphinerandomized trial

Morphine Does Not Relieve Chronic Breathlessness: The MABEL Trial Finds No Benefit and Signals More Harms

By MedXY|Nov 24, 2025

A UK multicentre randomized placebo‑controlled trial (MABEL) showed no improvement in worst breathlessness with low‑dose oral morphine versus placebo at 28 days, with more adverse events and withdrawals in the morphine arm.

Therapist-Guided e‑Health Cuts Fear of Cancer Recurrence in Colorectal Survivors: A Randomized Trial Shows Clinically Meaningful Benefits
AIcolorectal cancere-health intervention

Therapist-Guided e‑Health Cuts Fear of Cancer Recurrence in Colorectal Survivors: A Randomized Trial Shows Clinically Meaningful Benefits

By MedXY|Nov 19, 2025

A Danish RCT of TG‑iConquerFear, a 10‑week therapist‑guided online program for colorectal cancer survivors with clinical fear of cancer recurrence (FCR), reduced FCR scores substantially compared with augmented self‑help at 3 months; the be

Remote Cognitive Training, Structured Rehabilitation and tDCS Failed to Improve Self‑Reported Cognitive Symptoms in Long COVID: Results from a 5‑Arm Phase 2 Randomized Trial
Infectious Diseaseslong COVIDrandomized trial

Remote Cognitive Training, Structured Rehabilitation and tDCS Failed to Improve Self‑Reported Cognitive Symptoms in Long COVID: Results from a 5‑Arm Phase 2 Randomized Trial

By MedXY|Nov 18, 2025

A multicenter phase 2 randomized trial found no differential benefit of adaptive computerized cognitive training, structured cognitive rehabilitation, or transcranial direct current stimulation (tDCS) versus active comparators for self‑repo

Genomically Matched Therapy Improves Response and PFS Across Advanced Solid Tumors: Phase 2 ROME Trial
newsadvanced solid tumorsgenomic profiling

Genomically Matched Therapy Improves Response and PFS Across Advanced Solid Tumors: Phase 2 ROME Trial

By MedXY|Nov 12, 2025

The randomized phase 2 ROME trial showed that genomically matched, MTB-guided therapy increased overall response rate and progression-free survival versus standard care in heavily pretreated advanced solid tumors, supporting a tumor-agnosti

Atosiban Did Not Improve Neonatal Outcomes for Threatened Preterm Birth at 30–34 Weeks: Results from the Multicentre APOSTEL 8 Trial
newsAtosibanpreterm birth

Atosiban Did Not Improve Neonatal Outcomes for Threatened Preterm Birth at 30–34 Weeks: Results from the Multicentre APOSTEL 8 Trial

By MedXY|Dec 15, 2025

In the APOSTEL 8 randomized trial, intravenous atosiban did not reduce a composite of perinatal mortality and severe neonatal morbidity versus placebo for threatened preterm birth at 30+0–33+6 weeks.

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