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Oral Realgar-Indigo Naturalis Formula Matches Arsenic Trioxide Efficacy in Non-High-Risk Acute Promyelocytic Leukemia: Insights from a Multicenter Randomized Trial

A pivotal multicenter randomized trial demonstrates that oral Realgar-Indigo naturalis formula (RIF) combined with ATRA is non-inferior to arsenic trioxide (ATO) plus ATRA, providing a simplified consolidation regimen for non-high-risk APL

Section: Clinical UpdatesOct 7, 2025

Minimizing Anesthesia in Transcatheter Aortic Valve Implantation: Insights from the DOUBLE-CHOICE Trial

The DOUBLE-CHOICE randomized trial demonstrates non-inferiority of isolated local anesthesia versus conscious sedation in transfemoral TAVI, suggesting a safe minimalist anesthesia strategy with potential trade-offs in patient comfort.

randomized trial

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Oral Realgar-Indigo Naturalis Formula Matches Arsenic Trioxide Efficacy in Non-High-Risk Acute Promyelocytic Leukemia: Insights from a Multicenter Randomized Trial

Minimizing Anesthesia in Transcatheter Aortic Valve Implantation: Insights from the DOUBLE-CHOICE Trial

Cerebral Embolic Protection and Cognitive Outcomes After TAVI: Insights from the BHF PROTECT-TAVI Trial

Cerebral Embolic Protection Fails to Preserve Cognitive Function After TAVI: Insights from the BHF PROTECT-TAVI Trial

Comparative Effectiveness of Cupping and Scraping Therapy Versus NSAIDs for Chronic Nonspecific Low-Back Pain: Insights from a Multicenter Randomized Trial

Can Kissing Save Your Smile? Exploring Its Potential Protective Role Against Dental Cavities

Evaluating Thigh-High Compression Stockings in Preventing Vasovagal Syncope Recurrence: Insights from a Randomized Sham-Controlled Trial

Evaluating Electronic Nudges to Enhance Guideline-Directed Therapy in Chronic Kidney Disease: Insights from the NUDGE-CKD Trial

Appendicectomy Plus Medical Therapy Significantly Reduces Relapse in Ulcerative Colitis: Insights from the ACCURE Trial

Therapist-Guided Internet CBT Cuts Bulimia Episodes: A Japanese Randomized Trial with Promising Clinical Implications

UK-ROX Trial: Conservative Oxygen Strategy in Mechanically Ventilated ICU Patients — No 90‑Day Survival Benefit

Ketogenic Diet vs Further Antiseizure Medication in Infants with Drug-Resistant Epilepsy: What the KIWE Trial Adds to Clinical Practice

Exercise Alone Matches Diet Plus Exercise for Hip Osteoarthritis Pain Relief, Large Randomized Trial Shows

Individualised Versus Standard 10-Day Antibiotic Therapy in Pediatric Febrile UTI: Insights from the INDI-UTI Trial

Routine Use of Cerebral Embolic Protection in TAVI: Evidence, Outcomes, and Clinical Implications

Acute Normovolemic Hemodilution in Cardiac Surgery: No Reduction in Allogeneic Transfusion—Insights from a Multinational Randomized Trial

Medial Opening Wedge High Tibial Osteotomy for Medial Compartment Knee Osteoarthritis: Evidence from a Randomized Controlled Trial

Structured vs Self-Guided Multidomain Lifestyle Interventions for Cognitive Health: Insights from the US POINTER Randomized Clinical Trial