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Arterial Spin Labeling Hemodynamic Metrics Predict Cognitive Decline and Small Vessel Disease Progression Over 11 Years
NeurologyNeuroimagingarterial spin labeling

Arterial Spin Labeling Hemodynamic Metrics Predict Cognitive Decline and Small Vessel Disease Progression Over 11 Years

By MedXY|Sep 19, 2026

This study demonstrates that arterial spin labeling spatial coefficient of variation (ASL-sCoV) correlates with cerebral small vessel disease burden and predicts cognitive decline over 11 years, outperforming traditional cerebral blood flow

CSF Biomarkers as Indicators of Disease Severity in Probable Cerebral Amyloid Angiopathy: Insights Beyond MRI
NeurologyMRI
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β-Amyloid

CSF Biomarkers as Indicators of Disease Severity in Probable Cerebral Amyloid Angiopathy: Insights Beyond MRI

By MedXY|Sep 6, 2026

This study demonstrates that cerebrospinal fluid beta-amyloid peptides correlate with MRI markers of disease severity in probable cerebral amyloid angiopathy, suggesting CSF biomarkers provide a direct measure of vascular amyloid burden, in

Unveiling Neuroimaging Patterns and Genotype-Phenotype Links in Noonan Syndrome: Insights from a Multicenter Cohort
Diabetes & EndocrinologyBrain MRIRAS/MAPK pathway

Unveiling Neuroimaging Patterns and Genotype-Phenotype Links in Noonan Syndrome: Insights from a Multicenter Cohort

By MedXY|Aug 28, 2026

A comprehensive multicenter study reveals frequent neuroimaging abnormalities in children with Noonan syndrome and elucidates their associations with genetic variants and neurological symptoms, enhancing understanding of brain involvement i

Mapping Cognitive Load in Novice Surgeons: Insights Into Brain Activation and Performance Under Stress
General SurgeryNeuroimagingvỏ não trước trán giữa

Mapping Cognitive Load in Novice Surgeons: Insights Into Brain Activation and Performance Under Stress

By MedXY|Aug 25, 2026

This study elucidates how escalating cognitive workload affects brain activation in novice surgical residents, revealing distinct neural patterns linked to performance resilience or decline during simulated suturing tasks.

Plasma Biomarkers for Neocortical Tau Burden
Neurologyタウ病理Plasma Proteins

Plasma Biomarkers for Neocortical Tau Burden

By MedXY|Aug 15, 2026

A multiprotein plasma panel improves detection of advanced neocortical tau pathology in Alzheimer’s disease risk individuals beyond p-tau217 alone, enhancing patient stratification and clinical trial selection.

Connectivity- vs Scalp-Based Targeting of Accelerated Transcranial Magnetic Stimulation for Depression: A Randomized Clinical Trial
Neurologytranscranial magnetic stimulationdepression

Connectivity- vs Scalp-Based Targeting of Accelerated Transcranial Magnetic Stimulation for Depression: A Randomized Clinical Trial

By MedXY|Aug 10, 2026

This randomized trial compared connectivity-based versus scalp-based targeting of accelerated TMS in treatment-resistant depression, showing greater antidepressant effects with individualized connectivity-guided targeting.

Unraveling the Link Between Cortical Microinfarcts and Superficial Siderosis in Cerebral Amyloid Angiopathy
NeurologyBệnh động mạch não do amyloidcortical microinfarcts

Unraveling the Link Between Cortical Microinfarcts and Superficial Siderosis in Cerebral Amyloid Angiopathy

By MedXY|Jul 5, 2026

This study reveals a spatiotemporal relationship between cortical microinfarcts and cortical superficial siderosis in cerebral amyloid angiopathy, suggesting that superficial siderosis may promote local ischemic injury and highlighting a po

Biological Age Outpaces Chronological Age in Predicting Cerebral Small Vessel Disease Progression
Cardiologybiological agingcognitive decline

Biological Age Outpaces Chronological Age in Predicting Cerebral Small Vessel Disease Progression

By MedXY|Apr 14, 2026

This longitudinal cohort study reveals that biomarker-based biological age, particularly KDMAge and PhenoAge residuals, significantly predicts progression of cerebral small vessel disease, including new lacunes and microbleeds, offering pot

Basal Ganglia Perivascular Spaces: A Dual-Risk Biomarker for Ischemic Stroke and Major Bleeding in Antithrombotic Therapy
Neurologycerebral small vessel diseaseLiệu pháp chống huyết khối

Basal Ganglia Perivascular Spaces: A Dual-Risk Biomarker for Ischemic Stroke and Major Bleeding in Antithrombotic Therapy

By MedXY|Mar 27, 2026

A large-scale prospective study identifies high basal ganglia perivascular space (BGPVS) burden as a significant predictor of both major bleeding and ischemic stroke in patients on antithrombotic regimens, offering a new imaging biomarker f

Beyond the Motor Cortex: Functional Network Mapping Redefines Cerebral Palsy Prediction After Neonatal Stroke
Neurologycerebral palsyConnectomics

Beyond the Motor Cortex: Functional Network Mapping Redefines Cerebral Palsy Prediction After Neonatal Stroke

By MedXY|Mar 20, 2026

A landmark study using lesion network mapping reveals that cerebral palsy after neonatal stroke is driven by disruptions in extensive functional networks, including the thalamus and cerebellum, rather than just localized motor cortex damage

Disentangling Cognitive Decline: The Interplay of White Matter Hyperintensities and Cortical Metabolism in Amyloid-Negative Patients
Clinical Updatescognitive impairmentglucose metabolism

Disentangling Cognitive Decline: The Interplay of White Matter Hyperintensities and Cortical Metabolism in Amyloid-Negative Patients

By MedXY|Mar 15, 2026

This review synthesizes findings on how periventricular white matter hyperintensities (PWMHs) drive cognitive impairment in Aβ-negative individuals through distinct metabolic mediation and direct structural pathways, highlighting the clinic

Mapping ADHD Heterogeneity: A New Frontier in Neurobiological Biotyping through Morphometric Similarity Networks
Clinical UpdatesADHDNeuroimaging

Mapping ADHD Heterogeneity: A New Frontier in Neurobiological Biotyping through Morphometric Similarity Networks

By MedXY|Mar 2, 2026

This review explores a groundbreaking study using normative modeling and morphometric similarity networks to identify three distinct neurobiological biotypes of ADHD, providing a framework for precision psychiatry.

Expanding the Thrombolysis Window: Tenecteplase Improves Outcomes in Late-Window Non-Large Vessel Occlusion Stroke
Neurologyischemic strokeNeuroimaging

Expanding the Thrombolysis Window: Tenecteplase Improves Outcomes in Late-Window Non-Large Vessel Occlusion Stroke

By MedXY|Feb 8, 2026

The OPTION trial reveals that tenecteplase administered 4.5 to 24 hours post-stroke in patients with non-large vessel occlusion and salvageable tissue significantly improves functional recovery, although it carries a higher risk of symptoma

Time-Dependent Topography: How Specific ASPECTS Regions Predict Outcomes in Early vs. Extended Window Large Vessel Occlusion Stroke
NeurologyASPECTSNeuroimaging

Time-Dependent Topography: How Specific ASPECTS Regions Predict Outcomes in Early vs. Extended Window Large Vessel Occlusion Stroke

By MedXY|Feb 4, 2026

A post-hoc analysis of 1,040 LVO stroke patients reveals that the prognostic value of specific brain regions varies significantly between early (0-6h) and extended (6-24h) time windows, identifying the insula, caudate, and M6 as early-windo

Predicting Stroke Recurrence: MRI Markers Outperform Location in Risk-Stratifying Patients with ICH and Atrial Fibrillation
Cardiologyatrial fibrillationNeuroimaging

Predicting Stroke Recurrence: MRI Markers Outperform Location in Risk-Stratifying Patients with ICH and Atrial Fibrillation

By MedXY|Jan 21, 2026

A secondary analysis of the PRESTIGE-AF trial reveals that specific MRI markers, including cortical superficial siderosis and macrohemorrhages, are more potent predictors of recurrent intracerebral hemorrhage than hematoma location alone, o

Targeting the Right Brain: Structural Subtyping and Vascular Profiles Predict Response to Lifestyle Interventions in Dementia Prevention
Neurologydementia preventionlifestyle intervention

Targeting the Right Brain: Structural Subtyping and Vascular Profiles Predict Response to Lifestyle Interventions in Dementia Prevention

By MedXY|Jan 20, 2026

A sub-analysis of the FINGER trial reveals that individuals with specific grey matter patterns and lower vascular risk derive the most structural brain benefit from multimodal lifestyle interventions, highlighting the potential for personal

Midlife Plasma GFAP as a Long-Term Sentinel for Cerebral Small Vessel Disease: A Decadal Prospective Study
Neurologybiomarkerscerebral small vessel disease

Midlife Plasma GFAP as a Long-Term Sentinel for Cerebral Small Vessel Disease: A Decadal Prospective Study

By MedXY|Jan 6, 2026

Elevated plasma glial fibrillary acidic protein (GFAP) in middle age independently predicts the progression of cerebral small vessel disease MRI markers nearly a decade later, suggesting its potential as an early-stage prognostic biomarker

Refining Risk Stratification: The IsCHEMiA Score Outperforms Existing Models in Predicting Poststroke Epilepsy
Neurologyischemic strokeNeuroimaging

Refining Risk Stratification: The IsCHEMiA Score Outperforms Existing Models in Predicting Poststroke Epilepsy

By MedXY|Jan 6, 2026

The IsCHEMiA score, an imaging-based risk model validated across international cohorts, offers superior prediction of poststroke epilepsy compared to previous tools. By integrating clinical and neuroimaging markers, it provides a precise fr

Beyond the Lungs: How Ambient Air Pollution Drives Alzheimer’s Neuropathology and Cognitive Decline
NeurologyAlzheimer's diseaseNeuroimaging

Beyond the Lungs: How Ambient Air Pollution Drives Alzheimer’s Neuropathology and Cognitive Decline

By MedXY|Jan 2, 2026

Emerging evidence confirms that air pollution, particularly PM2.5 and NO2, is directly associated with Alzheimer’s neuropathology, structural brain changes, and cognitive decline. New research highlights that these effects are partially med

Deep Transfer Learning and Preimplant MRI: A Paradigm Shift in Predicting Pediatric Cochlear Implant Outcomes
AICochlear ImplantsNeuroimaging

Deep Transfer Learning and Preimplant MRI: A Paradigm Shift in Predicting Pediatric Cochlear Implant Outcomes

By MedXY|Dec 29, 2025

A multicenter study demonstrates that deep transfer learning (DTL) algorithms using preimplant MRI can predict spoken language development in children with cochlear implants with over 92% accuracy, significantly outperforming traditional ma

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