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Mapping the Neuro-Immune Divide: Distinct Brain-Blood Signatures Distinguish Early Depression from Psychosis
newsinflammationNeuroimaging

Mapping the Neuro-Immune Divide: Distinct Brain-Blood Signatures Distinguish Early Depression from Psychosis

By MedXY|Dec 24, 2025

A large-scale multicenter study identifies unique multivariate patterns of peripheral inflammation and brain structure that differentiate early-stage depression and psychosis, highlighting the influence of childhood trauma and cognitive per

Elevated Serotonin Release in Schizophrenia: New Insights Into Negative Symptom Pathophysiology
NeurologyNeuroimagingschizophrenia

Elevated Serotonin Release in Schizophrenia: New Insights Into Negative Symptom Pathophysiology

© 2026 MedXY
Contact usAbout usPrivacy PolicyMedXY story
By MedXY|Dec 17, 2025

A PET imaging study reveals increased frontal serotonin release in schizophrenia, particularly in deficit type, tied to worse negative symptoms.

Oral Valiltramiprosate in APOEε4/ε4 Carriers with Early Alzheimer’s Disease: Insights from the Phase III APOLLOE4 Trial
NeurologyAlzheimer's diseaseAPOEε4

Oral Valiltramiprosate in APOEε4/ε4 Carriers with Early Alzheimer’s Disease: Insights from the Phase III APOLLOE4 Trial

By MedXY|Oct 21, 2025

This phase III trial evaluated oral valiltramiprosate in APOEε4/ε4 homozygotes with early Alzheimer’s, showing brain atrophy slowing but limited overall clinical benefit, with nominal improvements in mild cognitive impairment subgroup

Amygdala Tau Pathology as a Key Contributor to Depressive Symptoms in Aging: Insights from Neuroimaging Studies
Neurologyagingamygdala

Amygdala Tau Pathology as a Key Contributor to Depressive Symptoms in Aging: Insights from Neuroimaging Studies

By MedXY|Oct 21, 2025

Amygdala tau accumulation in cognitively normal older adults correlates with worsening depressive symptoms, especially in APOE ε4 carriers, highlighting its role in neuropsychiatric changes during aging.

APOE ε4 Allele: A Key Driver of Cognitive Decline and Neurodegeneration in Older Adults from the Democratic Republic of the Congo
Family Medicine & NutritionAPOE ε4cognitive decline

APOE ε4 Allele: A Key Driver of Cognitive Decline and Neurodegeneration in Older Adults from the Democratic Republic of the Congo

By MedXY|Oct 21, 2025

This study reveals that the APOE ε4 allele is linked to increased dementia prevalence, cognitive deficits, brain atrophy, and plasma biomarkers of neurodegeneration in older adults in the DRC, emphasizing its critical role in African popula

Lifetime Walking Intensity and Duration Reduce Amyloid-β Accumulation in Alzheimer’s Disease: Insights from a Korean Longitudinal Cohort
Family Medicine & NutritionAlzheimer's diseaseAmyloid-β

Lifetime Walking Intensity and Duration Reduce Amyloid-β Accumulation in Alzheimer’s Disease: Insights from a Korean Longitudinal Cohort

By MedXY|Oct 20, 2025

A 4-year longitudinal study reveals that long-duration, high-intensity lifetime walking is associated with reduced amyloid-β accumulation in older adults, suggesting a neuroprotective effect when initiated early in life.

Delays in Pediatric Cannabis Toxicology Testing Lead to Increased Neuroimaging in Emergency Departments
Emergency MedicineNeuroimagingpediatric emergency

Delays in Pediatric Cannabis Toxicology Testing Lead to Increased Neuroimaging in Emergency Departments

By MedXY|Oct 9, 2025

Delayed cannabis test results in children under 6 with poisoning symptoms prolong ED visits and influence neuroimaging use. Faster toxicology screening could optimize care and reduce unnecessary scans.

Sex-Specific Brain Volume Loss After Traumatic Brain Injury: Greater Impact in Older Women
NeurologyBrain AtrophyNeuroimaging

Sex-Specific Brain Volume Loss After Traumatic Brain Injury: Greater Impact in Older Women

By MedXY|Sep 30, 2025

A study from the Framingham Heart Study cohort reveals that traumatic brain injury (TBI) is linked to significant brain volume loss in older women but not men, highlighting sex-specific vulnerability to neurodegeneration post-TBI.

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