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long-term outcomes

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Safety and Long-Term Benefits of Hormone Therapy After Chemoradiation in Young Cervical Cancer Survivors

Safety and Long-Term Benefits of Hormone Therapy After Chemoradiation in Young Cervical Cancer Survivors

By MedXY|Jul 20, 2026

Hormone therapy initiated within one year after chemoradiotherapy in young patients with locally advanced cervical cancer is associated with reduced metabolic, skeletal, and cerebrovascular risks, and improved survival without increased onc

Decade-Long Outcomes of Surgical Options in Rectal Endometriosis: Insights from a Robust Randomized Trial

General Surgery

Decade-Long Outcomes of Surgical Options in Rectal Endometriosis: Insights from a Robust Randomized Trial

By MedXY|Jul 16, 2026

A 10-year follow-up of a randomized trial comparing conservative nodule excision with segmental resection for rectal endometriosis reveals comparable long-term functional outcomes, low recurrence rates, and sustained symptomatic relief.

Comparing Long-Term Efficacy and Safety of Native Tissue Hysteropexy Versus Hysterectomy for Apical Pelvic Organ Prolapse

Comparing Long-Term Efficacy and Safety of Native Tissue Hysteropexy Versus Hysterectomy for Apical Pelvic Organ Prolapse

By MedXY|Jul 13, 2026

This study compares long-term retreatment rates and short-term complications in women undergoing native tissue hysteropexy versus hysterectomy with apical suspension for pelvic organ prolapse, revealing higher retreatment risk but fewer ear

Ten-Year Comparative Outcomes of Sacrospinous Hysteropexy With Mesh Versus Vaginal Hysterectomy for Uterovaginal Prolapse: Long-Term Efficacy and Safety

General Surgery

Ten-Year Comparative Outcomes of Sacrospinous Hysteropexy With Mesh Versus Vaginal Hysterectomy for Uterovaginal Prolapse: Long-Term Efficacy and Safety

By MedXY|Jul 8, 2026

This 10-year randomized clinical trial reveals that sacrospinous hysteropexy with mesh offers lower failure rates and comparable safety to vaginal hysterectomy in treating uterovaginal prolapse, supporting its use as an effective uterine-pr

Comparing Early Restrictive and Liberal Fluid Strategies in Sepsis-Induced Hypotension: Long-Term Effects on Patient-Centered Outcomes

Comparing Early Restrictive and Liberal Fluid Strategies in Sepsis-Induced Hypotension: Long-Term Effects on Patient-Centered Outcomes

By MedXY|Jul 5, 2026

A randomized trial showed no significant differences in 6- and 12-month cognitive, physical, and quality of life outcomes between early restrictive and liberal fluid resuscitation in sepsis-induced hypotension.

Reevaluating the Ross Procedure in Adults: Insights from a Large Contemporary Cohort

Reevaluating the Ross Procedure in Adults: Insights from a Large Contemporary Cohort

By MedXY|Jun 24, 2026

The Ross procedure in adults demonstrates excellent long-term survival, valve durability, and low reintervention rates, supporting its broader use in selected patients at experienced centers.

Decade-Long Outcomes of SAPIEN 3 TAVR vs. Surgery in Intermediate-Risk Aortic Stenosis Patients

Decade-Long Outcomes of SAPIEN 3 TAVR vs. Surgery in Intermediate-Risk Aortic Stenosis Patients

By MedXY|Jun 20, 2026

This analysis reveals comparable 10-year mortality, valve durability, and hemodynamics between SAPIEN 3 transcatheter and surgical aortic valve replacement in intermediate-risk patients, underscoring TAVR’s durable benefit.

10-Year Randomized Outcomes of Transcatheter or Surgical Aortic Valve Replacement in Intermediate-Risk Aortic Stenosis: What PARTNER 2A Adds to the Long-Term TAVR Evidence Base

10-Year Randomized Outcomes of Transcatheter or Surgical Aortic Valve Replacement in Intermediate-Risk Aortic Stenosis: What PARTNER 2A Adds to the Long-Term TAVR Evidence Base

By MedXY|Jun 17, 2026

The PARTNER 2A 10-year data show higher mortality and reintervention with balloon-expandable SAPIEN XT TAVR versus surgery in intermediate-risk patients, driven mainly by transthoracic access. Contemporary 10-year SAPIEN 3 data, however, su

Internet-Based CBT for Tinnitus Shows Durable Benefit Up to 6 Years, but Long-Term Interpretation Requires Caution

Internet-Based CBT for Tinnitus Shows Durable Benefit Up to 6 Years, but Long-Term Interpretation Requires Caution

By MedXY|Jun 1, 2026

A 6-year follow-up of guided internet-based CBT for tinnitus found sustained reductions in tinnitus distress, with smaller persistent gains in mood and sleep, despite substantial attrition and the absence of a long-term control group.

Internet-Based CBT for Tinnitus Shows Durable Benefit Up to 6 Years, With Sustained Reduction in Distress but More Modest Auditory Gains

Internet-Based CBT for Tinnitus Shows Durable Benefit Up to 6 Years, With Sustained Reduction in Distress but More Modest Auditory Gains

By MedXY|Jun 1, 2026

A 6-year follow-up study suggests guided internet-based CBT for tinnitus can produce durable reductions in tinnitus distress, with sustained but smaller benefits for mood, insomnia, and life satisfaction.

Biliopancreatic Diversion for Severe Obesity: Landmark 50-Year Study Reveals Lifelong Benefits and Risks

Diabetes & Endocrinology

Biliopancreatic Diversion for Severe Obesity: Landmark 50-Year Study Reveals Lifelong Benefits and Risks

By MedXY|May 11, 2026

A 50-year follow-up of biliopancreatic diversion shows sustained weight loss and diabetes remission, but alarmingly high nutritional complications decades after surgery.

Low-Intensity Motivational Intervention Shows Durable Benefits 5 Years After Stroke: Insights from the TaCAS Long-Term Follow-Up

Low-Intensity Motivational Intervention Shows Durable Benefits 5 Years After Stroke: Insights from the TaCAS Long-Term Follow-Up

By MedXY|Jan 21, 2026

The TaCAS long-term follow-up study reveals that a simple, conversation-based intervention can sustain improvements in physical health and independence for up to six years post-stroke, highlighting the lasting impact of patient-centered mot

The Long Shadow of the ICU: Identifying High-Risk Functional Trajectories in Older Survivors

The Long Shadow of the ICU: Identifying High-Risk Functional Trajectories in Older Survivors

By MedXY|Dec 26, 2025

A large-scale longitudinal study reveals that ICU survivors aged 60–79 face significantly higher 5-year excess mortality and functional decline compared to the general population, whereas outcomes for nonagenarians converge with their peers

Five-Year Safety of Avoiding Biopsy After Negative MRI in Prostate Cancer Pathways

Five-Year Safety of Avoiding Biopsy After Negative MRI in Prostate Cancer Pathways

By MedXY|Dec 17, 2025

Long-term data show RAPID MRI-directed pathway safely avoids unnecessary biopsies while maintaining low rates of clinically significant prostate cancer.

Early Neuromuscular Electrical Stimulation Plus Mobilization Improves 6‑Month Function and Quality of Life After Critical Illness

Early Neuromuscular Electrical Stimulation Plus Mobilization Improves 6‑Month Function and Quality of Life After Critical Illness

By MedXY|Dec 14, 2025

In a randomized, blinded trial of 74 mechanically ventilated ICU patients, adding early NMES to an early mobilization program started within 48 hours improved functional status, independence, mobility, and quality of life up to 6 months aft

Five-Year Survival and Quality of Life After ECMO: Good Long-Term Outcomes but Persistent Functional Burden

Five-Year Survival and Quality of Life After ECMO: Good Long-Term Outcomes but Persistent Functional Burden

By MedXY|Dec 11, 2025

A large prospective Dutch cohort reports 36% five-year survival after ECMO with generally satisfactory health-related quality of life (median EQ-5D 0.82) but ongoing problems with pain, mobility, activities, and work capacity.

Simple Discharge Subtypes Predict 3‑Month Mortality and 1‑Year Disability After Sepsis: Validation in the CLOVERS Cohort

Simple Discharge Subtypes Predict 3‑Month Mortality and 1‑Year Disability After Sepsis: Validation in the CLOVERS Cohort

By MedXY|Dec 9, 2025

A parsimonious discharge‑subtype algorithm applied to CLOVERS trial survivors stratified patients by 3‑month mortality and 12‑month functional outcomes, offering a pragmatic tool to target post‑hospital recovery resources.

Hospital Acute Kidney Injury Strongly Linked to Long-Term Death, Dialysis, and CKD: Meta-Analysis of Matched-Control Studies

Hospital Acute Kidney Injury Strongly Linked to Long-Term Death, Dialysis, and CKD: Meta-Analysis of Matched-Control Studies

By MedXY|Dec 9, 2025

A meta-analysis of 14 matched-control studies (n=1,058,109) finds that survivors of in-hospital AKI face higher long-term mortality, greater subsequent dialysis need, and elevated risk of CKD versus matched controls.

Seven-Year Outcomes of TAVR vs. Surgical Aortic Valve Replacement in Low-Risk Patients: Insights from PARTNER 3

Seven-Year Outcomes of TAVR vs. Surgical Aortic Valve Replacement in Low-Risk Patients: Insights from PARTNER 3

By MedXY|Oct 31, 2025

At 7 years, transcatheter and surgical aortic valve replacement show comparable outcomes including survival, stroke, and valve durability among low-risk patients with severe aortic stenosis, affirming TAVR’s long-term efficacy.

Long-Term Safety and Efficacy of Gene Therapy for Adenosine Deaminase Deficiency

Allergy & Immunology

Long-Term Safety and Efficacy of Gene Therapy for Adenosine Deaminase Deficiency

By MedXY|Oct 25, 2025

This study demonstrates the long-term effectiveness and safety of autologous gene therapy for treating ADA deficiency, showing sustained immune function and minimal adverse effects over a median follow-up of 7.5 years.

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