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Five-Year Safety of Avoiding Biopsy After Negative MRI in Prostate Cancer Pathways
newsbiopsylong-term outcomes

Five-Year Safety of Avoiding Biopsy After Negative MRI in Prostate Cancer Pathways

By MedXY|Dec 17, 2025

Long-term data show RAPID MRI-directed pathway safely avoids unnecessary biopsies while maintaining low rates of clinically significant prostate cancer.

Early Neuromuscular Electrical Stimulation Plus Mobilization Improves 6‑Month Function and Quality of Life After Critical Illness
Critical Careearly mobilizationICU‑acquired weakness

Early Neuromuscular Electrical Stimulation Plus Mobilization Improves 6‑Month Function and Quality of Life After Critical Illness

By MedXY|Dec 14, 2025

In a randomized, blinded trial of 74 mechanically ventilated ICU patients, adding early NMES to an early mobilization program started within 48 hours improved functional status, independence, mobility, and quality of life up to 6 months aft

Five-Year Survival and Quality of Life After ECMO: Good Long-Term Outcomes but Persistent Functional Burden
Critical Carecritical careECMO

Five-Year Survival and Quality of Life After ECMO: Good Long-Term Outcomes but Persistent Functional Burden

By MedXY|Dec 11, 2025

A large prospective Dutch cohort reports 36% five-year survival after ECMO with generally satisfactory health-related quality of life (median EQ-5D 0.82) but ongoing problems with pain, mobility, activities, and work capacity.

Simple Discharge Subtypes Predict 3‑Month Mortality and 1‑Year Disability After Sepsis: Validation in the CLOVERS Cohort
Critical Carelong-term outcomessubtyping

Simple Discharge Subtypes Predict 3‑Month Mortality and 1‑Year Disability After Sepsis: Validation in the CLOVERS Cohort

By MedXY|Dec 9, 2025

A parsimonious discharge‑subtype algorithm applied to CLOVERS trial survivors stratified patients by 3‑month mortality and 12‑month functional outcomes, offering a pragmatic tool to target post‑hospital recovery resources.

Hospital Acute Kidney Injury Strongly Linked to Long-Term Death, Dialysis, and CKD: Meta-Analysis of Matched-Control Studies
Critical Careacute kidney injurychronic kidney disease

Hospital Acute Kidney Injury Strongly Linked to Long-Term Death, Dialysis, and CKD: Meta-Analysis of Matched-Control Studies

By MedXY|Dec 9, 2025

A meta-analysis of 14 matched-control studies (n=1,058,109) finds that survivors of in-hospital AKI face higher long-term mortality, greater subsequent dialysis need, and elevated risk of CKD versus matched controls.

Seven-Year Outcomes of TAVR vs. Surgical Aortic Valve Replacement in Low-Risk Patients: Insights from PARTNER 3
Cardiologyaortic stenosislong-term outcomes

Seven-Year Outcomes of TAVR vs. Surgical Aortic Valve Replacement in Low-Risk Patients: Insights from PARTNER 3

By MedXY|Oct 31, 2025

At 7 years, transcatheter and surgical aortic valve replacement show comparable outcomes including survival, stroke, and valve durability among low-risk patients with severe aortic stenosis, affirming TAVR’s long-term efficacy.

Long-Term Safety and Efficacy of Gene Therapy for Adenosine Deaminase Deficiency
Allergy & Immunologygene therapylong-term outcomes

Long-Term Safety and Efficacy of Gene Therapy for Adenosine Deaminase Deficiency

By MedXY|Oct 25, 2025

This study demonstrates the long-term effectiveness and safety of autologous gene therapy for treating ADA deficiency, showing sustained immune function and minimal adverse effects over a median follow-up of 7.5 years.

Long-Term Outcomes of Extracranial Vertebral Artery Reconstruction in Managing Symptomatic Vertebral Artery In-Stent Restenosis or Occlusion
Cardiologylong-term outcomesstroke prevention

Long-Term Outcomes of Extracranial Vertebral Artery Reconstruction in Managing Symptomatic Vertebral Artery In-Stent Restenosis or Occlusion

By MedXY|Oct 24, 2025

This study evaluates the efficacy of vertebral artery reconstruction surgery versus medical therapy in reducing stroke recurrence and improving neurological outcomes over a ten-year period.

Long-Term Outcomes of Oral Implant Rehabilitation in Patients with Disabilities Under General Anesthesia: A 14-Year Cohort Study
Dentistrycohort studydisability

Long-Term Outcomes of Oral Implant Rehabilitation in Patients with Disabilities Under General Anesthesia: A 14-Year Cohort Study

By MedXY|Oct 23, 2025

This study evaluates the safety, effectiveness, and longevity of implant-supported prostheses in disabled patients treated under general anesthesia over 14 years.

Long-Term Comparative Outcomes of Gastric Bypass and Sleeve Gastrectomy in Type 2 Diabetes: Evidence from a Swedish Matched Cohort Study
Diabetes & EndocrinologyGastric Bypasslong-term outcomes

Long-Term Comparative Outcomes of Gastric Bypass and Sleeve Gastrectomy in Type 2 Diabetes: Evidence from a Swedish Matched Cohort Study

By MedXY|Oct 19, 2025

A Swedish nationwide study reveals Roux-en-Y gastric bypass yields superior long-term benefits in type 2 diabetes remission and reduced mortality compared to sleeve gastrectomy, despite higher risks of nutritional deficiencies and psychiatr

Early Adolescent Mental Well-Being as a Predictor of Long-Term Health Outcomes
Psychiatryadolescent mental healthlong-term outcomes

Early Adolescent Mental Well-Being as a Predictor of Long-Term Health Outcomes

By MedXY|Oct 18, 2025

This study highlights how poor mental well-being during adolescence predicts increased risks of mental illness, risky behaviors, and mortality in young adulthood, emphasizing the urgency for early identification and intervention.

Long-Term Outcomes of Transcatheter Versus Surgical Aortic Valve Replacement: A Meta-Analysis of Time-to-Event Data
Cardiologyaortic valve replacementlong-term outcomes

Long-Term Outcomes of Transcatheter Versus Surgical Aortic Valve Replacement: A Meta-Analysis of Time-to-Event Data

By MedXY|Oct 12, 2025

This meta-analysis evaluates 5-year outcomes comparing TAVI and SAVR across risk profiles, revealing early advantages with TAVI that level off long-term, with no significant difference at 5 years.

Evaluating Long-Term Outcomes of Contemporary Arthroscopic Bankart Repair in Traumatic Anterior Shoulder Instability: Insights From a 10-Year Follow-Up Study
newslong-term outcomesRecurrence rate

Evaluating Long-Term Outcomes of Contemporary Arthroscopic Bankart Repair in Traumatic Anterior Shoulder Instability: Insights From a 10-Year Follow-Up Study

By MedXY|Oct 10, 2025

This study examines long-term outcomes of a modern arthroscopic Bankart repair technique for traumatic anterior shoulder instability over a minimum 10-year follow-up, highlighting recurrence rates, risk factors, and functional results.

Assessing the Long-Term Risk of Mesh Removal Due to Infection After Elective Ventral Hernia Repair
General Surgerylong-term outcomes

Assessing the Long-Term Risk of Mesh Removal Due to Infection After Elective Ventral Hernia Repair

By MedXY|Oct 10, 2025

A decade-long Medicare study shows low overall risk of mesh removal from infection after open ventral hernia repair, with a slightly higher risk in patients experiencing early wound complications.

Balancing Risks and Benefits: Early Antipsychotic Dose Reduction Versus Maintenance After First-Episode Psychosis Remission
Clinical Updatesantipsychoticsdose reduction

Balancing Risks and Benefits: Early Antipsychotic Dose Reduction Versus Maintenance After First-Episode Psychosis Remission

By MedXY|Oct 6, 2025

A randomized clinical trial reveals early dose reduction of antipsychotics after first-episode psychosis remission increases short-term relapse risk and lowers quality of life, but may improve long-term functioning over four years.

Sustained Symptom Control over Five Years: Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson Disease
Neurologylong-term outcomesParkinson disease

Sustained Symptom Control over Five Years: Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson Disease

By MedXY|Oct 9, 2025

Five-year follow-up from the INTREPID trial confirms that subthalamic nucleus deep brain stimulation significantly improves motor symptoms, reduces dyskinesia, lowers medication needs, and enhances daily living activities in moderate to adv

Early Control of Ulcerative Colitis and Its Impact on Long-Term Outcomes: Insights from the UNIFI Phase 3 Study
Clinical Updateslong-term outcomesulcerative colitis

Early Control of Ulcerative Colitis and Its Impact on Long-Term Outcomes: Insights from the UNIFI Phase 3 Study

By MedXY|Oct 5, 2025

Achieving disease clearance early after induction therapy with ustekinumab in ulcerative colitis patients predicts sustained clinical remission, symptom control, and improved quality of life over four years.

Nine-Year Outcomes After Lacunar and Mild Cortical Ischemic Stroke: Long-Term Functional, Cognitive, and Vascular Impacts
Clinical Updatescognitive declinelacunar stroke

Nine-Year Outcomes After Lacunar and Mild Cortical Ischemic Stroke: Long-Term Functional, Cognitive, and Vascular Impacts

By MedXY|Oct 5, 2025

This longitudinal study reveals persistent cognitive, physical, and vascular challenges up to 9 years after minor lacunar or cortical ischemic stroke, emphasizing different risks and recovery patterns by stroke subtype.

Long-Term Durability of Active Surveillance in Small, Low-Risk Papillary Thyroid Cancer: Age-Related Outcomes and Clinical Implications
Oncologyactive surveillancelong-term outcomes

Long-Term Durability of Active Surveillance in Small, Low-Risk Papillary Thyroid Cancer: Age-Related Outcomes and Clinical Implications

By MedXY|Oct 4, 2025

Active surveillance is a durable management strategy for small, low-risk papillary thyroid cancer, especially among older adults who show significantly lower crossover rates to surgery.

Serum Alpha-Linolenic Acid and Long-Term Multiple Sclerosis Activity and Progression: Insights from the BENEFIT Study
Allergy & Immunologylong-term outcomesmultiple sclerosis

Serum Alpha-Linolenic Acid and Long-Term Multiple Sclerosis Activity and Progression: Insights from the BENEFIT Study

By MedXY|Oct 4, 2025

Higher baseline serum alpha-linolenic acid levels predict reduced multiple sclerosis activity, relapses, and disability progression up to 11 years post clinical onset in a large prospective study.

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