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Levothyroxine in Pregnancy for Subclinical Hypothyroidism or Hypothyroxinemia: No Benefit on Child IQ

By MedXY|Jul 28, 2026

A randomized trial found that levothyroxine treatment for subclinical hypothyroidism or hypothyroxinemia starting between 8 and 20 weeks of gestation did not improve IQ scores in children at age 5 years compared with placebo.

Levothyroxine Dosing and the Risk of Suboptimal Thyroid Control: Insights from a Large Real-World Longitudinal Study

Diabetes & Endocrinologydose-response

levothyroxine

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Levothyroxine in Pregnancy for Subclinical Hypothyroidism or Hypothyroxinemia: No Benefit on Child IQ

Levothyroxine Dosing and the Risk of Suboptimal Thyroid Control: Insights from a Large Real-World Longitudinal Study

Prevalence and Clinical Characteristics of Macro-TSH in Patients with Subclinical Hypothyroidism

Phase 2 Study of XP-8121: Once-Weekly Subcutaneous Levothyroxine for Adult Hypothyroidism

Levothyroxine in the Ageing Patient: Re-evaluating Cardiovascular Outcomes in Subclinical Hypothyroidism through the ACEL-UK-ETT Trial

Breaking the Fasting Mandate: Is It Time to Re-evaluate Levothyroxine Administration?

Levothyroxine Monotherapy in Midlife Women: Long-Term SWAN Data Reassures on Cardiovascular Safety

Levothyroxine Supplementation: A Critical Tool for Reducing Pregnancy Loss and Preterm Delivery in Thyroid Dysfunction