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Reevaluating Colorectal Cancer Surveillance in Inflammatory Bowel Disease: The Role of Family History Beyond Early-Onset Cases
Gastroenterologycancer surveillancefamily history

Reevaluating Colorectal Cancer Surveillance in Inflammatory Bowel Disease: The Role of Family History Beyond Early-Onset Cases

By MedXY|Sep 6, 2026

A nationwide cohort study reveals that in IBD patients, colorectal cancer risk increases notably with multiple affected relatives, challenging current guidelines prioritizing early-onset family history for surveillance.

Early Childhood Exposure to Crohn’s Disease-Affected Siblings: Implications for Gut Microbiome and Disease Susceptibility
GastroenterologyCrohn’s disease
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Sibling exposure

Early Childhood Exposure to Crohn’s Disease-Affected Siblings: Implications for Gut Microbiome and Disease Susceptibility

By MedXY|Aug 28, 2026

Childhood exposure to siblings with Crohn’s disease significantly raises disease risk, linked to distinct gut microbiome changes that may drive disease onset through immune modulation.

Outcomes of Colorectal Dysplasia and Cancer in Patients with PSC-IBD Undergoing Liver Transplantation and Colectomy: Insights from a Multicenter Study
Gastroenterologycolorectal cancerinflammatory bowel disease

Outcomes of Colorectal Dysplasia and Cancer in Patients with PSC-IBD Undergoing Liver Transplantation and Colectomy: Insights from a Multicenter Study

By MedXY|Jul 15, 2026

This multicenter retrospective study examines colorectal dysplasia and malignancy outcomes in patients with primary sclerosing cholangitis and inflammatory bowel disease undergoing liver transplantation and colectomy, revealing comparable 5

Impact of Acetaldehyde Metabolism on Alcohol-Related Inflammatory Bowel Disease Risk: A Precision Medicine Perspective
GastroenterologyAcetaldehyde MetabolismAlcohol Consumption

Impact of Acetaldehyde Metabolism on Alcohol-Related Inflammatory Bowel Disease Risk: A Precision Medicine Perspective

By MedXY|Jul 3, 2026

This study elucidates how genetic differences in acetaldehyde metabolism modify the risk of alcohol-associated inflammatory bowel disease (IBD), highlighting personalized prevention strategies.

IBDome: Integrating Molecular, Histopathological, and Clinical Data to Transform Inflammatory Bowel Disease Management
GastroenterologyHistopathologyinflammatory bowel disease

IBDome: Integrating Molecular, Histopathological, and Clinical Data to Transform Inflammatory Bowel Disease Management

By MedXY|Jul 3, 2026

IBDome offers a comprehensive multiomic atlas integrating molecular, histopathological, and clinical data, advancing the understanding and precision treatment of Crohn’s disease and ulcerative colitis.

Colonic GPR15L Emerges as a Microbiota-Shaping Host-Defense Peptide That Protects Against Experimental Colitis
Allergy & ImmunologycolitisGPR15L

Colonic GPR15L Emerges as a Microbiota-Shaping Host-Defense Peptide That Protects Against Experimental Colitis

By MedXY|Jun 10, 2026

New data identify GPR15L as an epithelial host-defense peptide that reshapes the colonic microbiota, reduces experimental colitis, and may have therapeutic relevance in inflammatory bowel disease.

Causal Insights Into Hidradenitis Suppurativa: Mendelian Randomization Evidence Linking BMI, Inflammatory Bowel Disease, and Smoking
Clinical UpdatesBMIhidradenitis suppurativa

Causal Insights Into Hidradenitis Suppurativa: Mendelian Randomization Evidence Linking BMI, Inflammatory Bowel Disease, and Smoking

By MedXY|Dec 24, 2025

Recent Mendelian randomization analyses demonstrate causal effects of increased BMI and inflammatory bowel disease on hidradenitis suppurativa risk, elucidating modifiable contributions beyond genetic correlations with psoriasis and systemi

Efficacy and Implementation of a Digital Cognitive Behavioural Self-Management Programme (IBD-BOOST) for Fatigue, Pain, and Faecal Incontinence in Inflammatory Bowel Disease: A Comprehensive Review
Clinical Updatesfatigueinflammatory bowel disease

Efficacy and Implementation of a Digital Cognitive Behavioural Self-Management Programme (IBD-BOOST) for Fatigue, Pain, and Faecal Incontinence in Inflammatory Bowel Disease: A Comprehensive Review

By MedXY|Nov 23, 2025

This review evaluates the IBD-BOOST digital cognitive behavioural self-management intervention’s design, trial outcomes, process evaluation, and clinical implications for managing fatigue, pain, and faecal incontinence in IBD.

IL23R Polymorphism as a Genetic Predictor of Paradoxical Psoriasis in Anti-TNFα-Treated IBD Patients
Dermatologyinflammatory bowel diseasepharmacogenetics

IL23R Polymorphism as a Genetic Predictor of Paradoxical Psoriasis in Anti-TNFα-Treated IBD Patients

By MedXY|Oct 9, 2025

The IL23R1142G>A genetic variant strongly predicts paradoxical psoriasis in inflammatory bowel disease patients undergoing anti-TNFα therapy, guiding personalized treatment decisions.

Gut Microbiota as a Key Determinant of Quality of Life Impairment in Inflammatory Bowel Disease
Gastroenterologygut microbiotainflammatory bowel disease

Gut Microbiota as a Key Determinant of Quality of Life Impairment in Inflammatory Bowel Disease

By MedXY|Oct 9, 2025

A recent cross-sectional study reveals that alterations in gut microbiota correlate more strongly with impaired health-related quality of life in IBD patients than clinical disease activity, suggesting novel microbial therapeutic targets be

Unraveling the Paradox: Why Smoking Benefits Ulcerative Colitis but Worsens Crohn’s Disease
GastroenterologyCrohn’s diseasegut microbiota

Unraveling the Paradox: Why Smoking Benefits Ulcerative Colitis but Worsens Crohn’s Disease

By MedXY|Oct 6, 2025

Recent research elucidates how smoking modulates gut microbiota and immune responses differently in ulcerative colitis and Crohn’s disease, explaining its protective effect in UC but detrimental role in CD.

Unmasking Fructose: How a Common Sweetener Sparks Immune Attacks and Inflammatory Bowel Disease—And How Metformin Offers Hope
Family Medicine & Nutritionfructoseimmune system

Unmasking Fructose: How a Common Sweetener Sparks Immune Attacks and Inflammatory Bowel Disease—And How Metformin Offers Hope

By MedXY|Oct 5, 2025

High fructose intake can directly activate immune cells, worsening intestinal inflammation linked to IBD, but the diabetes drug metformin shows promise in reversing these effects.

Afimkibart, an Anti-TL1A Antibody, in Moderately-to-Severely Active Ulcerative Colitis: Insights from the Phase 2b TUSCANY-2 Trial
Clinical Updatesclinical trialinflammatory bowel disease

Afimkibart, an Anti-TL1A Antibody, in Moderately-to-Severely Active Ulcerative Colitis: Insights from the Phase 2b TUSCANY-2 Trial

By MedXY|Oct 5, 2025

The TUSCANY-2 phase 2b trial evaluated afimkibart, a novel anti-TL1A antibody, in moderately-to-severely active ulcerative colitis, demonstrating favorable safety and clinically meaningful remission rates using modified Mayo scores despite

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