Disrupted Microbial Metabolism in Gut Inflammation as a Key Driver of Adverse Food Reactions in IBD

Highlight

• Intestinal inflammation disrupts gut microbial metabolism of food antigens, facilitating food sensitization.
• Inflammation-driven depletion of specific colonic bacteria impairs digestion of food triggers, enhancing IgE-mediated immune responses.
• Mast cell recruitment and activation in the colon mediate visceral pain and low-grade inflammation upon re-exposure to sensitizing foods.
• In IBD patients, self-reported food intolerances correlate with microbial alterations and reduced food-metabolizing bacteria, suggesting translational relevance.

Study Background