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PhysioSync-HF trial reveals CSP is inferior to BiVP for HFrEF patients with LBBB, challenging its role as a first-line resynchronization therapy despite cost benefits.
The HeartSync-LBBP trial reveals left bundle-branch pacing reduces the composite of death or heart failure hospitalization by 74% compared to biventricular pacing, with significantly higher super-response rates in patients with reduced ejec
![Persistent Fibroblast Activation Predicts Heart Failure Progression: [68Ga]FAPI-46 PET/MRI Reveals Distinct Patterns in Ischemic and Nonischemic Cardiomyopathy](https://news.medxy.ai/wp-content/uploads/2026/04/d43c8ff0-6629-4944-bc15-78efd79810d7-600x600.jpg)
A prospective case-control study demonstrates that myocardial fibroblast activation persists in heart failure patients and follows distinct spatial patterns depending on etiology. Using [68Ga]FAPI-46 PET/MRI, researchers found that higher b
A landmark study reveals that exercise-induced multi-organ physiologic deficits strongly predict incident heart failure with preserved ejection fraction (HFpEF). Using invasive cardiopulmonary testing, metabolomics, and genomics across over
A canine study reveals left bundle branch pacing achieves equivalent QRS narrowing and ejection fraction improvement as biventricular pacing, yet demonstrates superior recovery of cardiac mechanics, calcium handling, and energy metabolism a
A groundbreaking mass spectrometry study analyzing 486 heart failure patients and 98 controls identified over 21,000 unique peptides, revealing 1,924 differentially expressed peptides. The research highlights angiotensin-related peptides, n
A large retrospective study of 52,850 veterans reveals that just 21.2% achieve guideline-directed quadruple therapy for HFrEF, with a median time of 197 days. Socioeconomic barriers, including prescription copays, emerge as critical modifia
This review synthesizes recent evidence identifying MR-proADM as a premier prognostic biomarker in ATTR-CM, demonstrating its ability to outperform traditional natriuretic peptides and enhance existing clinical staging systems.
A large-scale registry analysis demonstrates that Transcatheter Edge-to-Edge Repair (TEER) significantly reduces mortality and heart failure hospitalizations in patients with atrial functional mitral regurgitation (AFMR) compared to medical
Researchers from the ARIC study have identified five specific proteomic markers that uniquely predict heart failure risk in individuals with diabetes. These findings, including four novel proteins, suggest distinct pathophysiological pathwa
This article examines the debate between JACC and ESC definitions for Atrial Functional Mitral Regurgitation (AfMR), highlighting why the JACC Expert Consensus offers a more robust framework for clinical prognosis and patient classification
A comprehensive review of the ARIC study’s identification of five unique proteomic markers—four novel—that specifically predict heart failure risk in patients with diabetes, offering new insights into lipid metabolism and inflammatory
This review analyzes the prognostic value of the 2022 Heart Failure staging in patients with diabetes and kidney disease, highlighting the high risk of asymptomatic ‘Pre-HF’ and the consistent therapeutic benefits of sotaglifloz
This article explores a major international study of 156 acute eosinophilic myocarditis patients, revealing high mortality rates, the diagnostic necessity of endomyocardial biopsy, and the critical survival benefit of early immunosuppressiv
The REVEAL-HCM study demonstrates that the prognostic impact of mitral regurgitation varies significantly across HCM subtypes, with notable risk in nonobstructive and apical forms, but not in obstructive or end-stage HCM.
A large-scale analysis of 239,890 patients in England reveals that Black, Asian, and mixed-ethnicity patients hospitalized for heart failure have significantly lower mortality rates than White patients, largely due to better pharmacological
A propensity score-based study demonstrates that transcatheter edge-to-edge repair (TEER) significantly reduces mortality and heart failure hospitalizations in patients with atrial functional mitral regurgitation compared to medical therapy
This article explores a groundbreaking study identifying CRLF1, a protein secreted by cardiac fibroblasts, as a key driver of Hypertrophic Cardiomyopathy (HCM). This paracrine signaling mechanism offers a potential universal therapeutic tar
This post hoc analysis of the CREDENCE trial reveals that low-normal sodium intake increases cardiovascular risk in T2D and CKD, a risk significantly mitigated by canagliflozin, while renal protection remains consistent across sodium intake
The EMPATICC trial explored heart failure therapy for patients with advanced cancer in palliative care. While it did not meet its primary endpoint for self-care ability due to high mortality, survivors showed improved cardiac biomarkers and