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This article evaluates the presence of micro- and nano-plastics in coronary blood of patients with ischemic heart disease, linking their burden to acute coronary events, air pollution exposure, and inflammation, highlighting a novel environ
The oxidized phospholipid PGPC inhibits angiogenesis in ischemic heart disease by impairing endothelial autophagic flux through NPC1-induced acetylation and ubiquitination of syntaxin 17, unveiling new potential therapeutic targets for coro
This review synthesizes emerging evidence from the PROACT trials on genotype-first identification of subclinical coronary atherosclerosis using polygenic risk scores (PRS), highlighting feasibility, engagement, and high prevalence of silent
Chronic exposure to fine particulate matter (PM2.5) is linked to epicardial coronary endothelial dysfunction, an early marker of coronary artery disease, as demonstrated by invasive coronary vasoreactivity testing.
The FAVOR III China trial demonstrates that QFR-guided percutaneous coronary intervention significantly reduces major adverse cardiac events over 5 years, mainly by decreasing myocardial infarction and ischemia-driven revascularization comp
In type 2 diabetes patients with coronary artery disease, suPAR levels remain unchanged despite treatment and independently predict adverse cardiovascular events beyond hs-CRP, highlighting suPAR’s potential in identifying treatment-r
Emerging evidence identifies circulating imidazole propionate, a gut microbiota-derived metabolite, as an independent predictor of major adverse cardiovascular events in patients with coronary artery disease, offering novel insights into pe
The TUXEDO-2 trial demonstrated that ultra-thin strut biodegradable polymer sirolimus-eluting stents are noninferior to durable polymer everolimus-eluting stents in diabetic patients with multivessel coronary artery disease at 1-year follow
Elevated lipoprotein(a) increases coronary artery disease risk, but this study reveals that inflammation—particularly IL-6 levels—modulates this risk, highlighting the importance of inflammatory biomarkers in cardiovascular risk assessment
ORBITA-FIRE shows that angina occurs at much lower, individualized FFR and RFR thresholds than standard ischemia cutoffs, and these thresholds rise with exercise intensity.
The RF-CL model is a new ESC-recommended tool for estimating the pre-test probability of obstructive CAD in suspected chronic coronary syndromes. It improves risk stratification and may reduce unnecessary testing, though symptom interpretat
A 19-year Finnish cohort study found that a higher waist-to-height ratio was linked to increased coronary artery disease risk in type 1 diabetes, especially in people without albuminuria.
In women with chronic severe coronary artery disease, CABG was linked to lower long-term rates of death, stroke, heart attack, repeat revascularization, and cardiovascular readmission than PCI.
In patients with prior PCI but no prior MI, evolocumab significantly lowered LDL-C and reduced major cardiovascular events, including myocardial infarction and urgent revascularization, supporting intensive lipid lowering after coronary int
ORBITA-2 reveals PCI’s superior placebo-controlled angina relief in focal vs. diffuse coronary artery disease, with physiological disease patterns guiding treatment decisions.
This review synthesizes evidence on the genetic architecture of adult-onset diabetes subtypes, highlighting that Moderate Obesity-related Diabetes (MOD) is uniquely and causally linked to coronary artery disease risk through polygenic and M
A landmark study in Diabetes Care reveals that soluble urokinase plasminogen activator receptor (suPAR) mediates over half of the increased risk for adverse cardiovascular outcomes in patients with diabetes and coronary artery disease, surp
This review synthesizes findings from a PROMISE trial substudy, revealing that quantitative coronary plaque volume and burden are independent predictors of MACE in symptomatic outpatients, even when total plaque levels are low.
A landmark nationwide study reveals that liver transplant recipients face significantly higher prevalence and severity of coronary atherosclerosis and high-risk plaque compared to matched controls, independent of traditional cardiovascular
A nationwide Swedish registry analysis demonstrates that routine PCI before TAVR for significant coronary artery disease does not improve survival or reduce urgent revascularization, but significantly increases bleeding risk while reducing
