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Beyond Stenosis: Why Quantitative Plaque Volume Is the New Frontier in Cardiovascular Risk Assessment
Cardiologycardiovascular riskCCTA

Beyond Stenosis: Why Quantitative Plaque Volume Is the New Frontier in Cardiovascular Risk Assessment

By MedXY|Feb 22, 2026

A substudy of the PROMISE trial demonstrates that quantitative plaque measures on CCTA—specifically total and noncalcified plaque burden—independently predict major adverse cardiovascular events in symptomatic outpatients, offering a precis

Abluminus DES+ Fails to Achieve Non-Inferiority Against XIENCE EES in Patients with Diabetes: Results from the ABILITY Diabetes Global Trial
Cardiologycoronary artery diseaseDiabetes Mellitus
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Abluminus DES+ Fails to Achieve Non-Inferiority Against XIENCE EES in Patients with Diabetes: Results from the ABILITY Diabetes Global Trial

By MedXY|Jan 18, 2026

The ABILITY Diabetes Global trial demonstrates that the Abluminus DES+ sirolimus-eluting stent failed to meet non-inferiority compared to the XIENCE everolimus-eluting stent in patients with diabetes, showing significantly higher rates of t

Validating the 0.80 FFR Threshold: Long-Term Outcomes from the NOTION-3 Trial in TAVR Patients
Cardiologycoronary artery diseaseFractional Flow Reserve

Validating the 0.80 FFR Threshold: Long-Term Outcomes from the NOTION-3 Trial in TAVR Patients

By MedXY|Jan 17, 2026

The NOTION-3 trial demonstrates that FFR-guided revascularization significantly reduces cardiovascular risks in TAVR patients with coronary artery disease, validating the 0.80 threshold for clinical decision-making.

Obstructive Coronary Artery Disease Does Not Diminish Long-Term Health Status or Clinical Efficacy After TAVR: 3-Year Insights from SCOPE I
CardiologyCardiologyclinical trials

Obstructive Coronary Artery Disease Does Not Diminish Long-Term Health Status or Clinical Efficacy After TAVR: 3-Year Insights from SCOPE I

By MedXY|Dec 21, 2025

A post hoc analysis of the SCOPE I trial reveals that obstructive coronary artery disease (CAD) does not significantly impact 3-year survival or patient-reported health status following TAVR, questioning the routine necessity of periprocedu

Reticulated Platelets Drive Prothrombotic Signalling in Coronary Artery Disease — GPVI and PI3K Identified as Actionable Targets
Cardiologycoronary artery diseaseGPVI

Reticulated Platelets Drive Prothrombotic Signalling in Coronary Artery Disease — GPVI and PI3K Identified as Actionable Targets

By MedXY|Dec 2, 2025

A multidimensional study of 95 CAD patients shows that RNA-rich reticulated platelets exhibit a distinct prothrombotic transcriptomic and proteomic signature with upregulated GPVI and PI3K signalling; GPVI and PI3K inhibition reduced RP-dri

CABG Provides Superior Long-Term Outcomes to PCI in Women with Chronic Severe CAD: Real‑World Ontario Cohort Shows Lower MACCE and Mortality
CardiologyCABGcoronary artery disease

CABG Provides Superior Long-Term Outcomes to PCI in Women with Chronic Severe CAD: Real‑World Ontario Cohort Shows Lower MACCE and Mortality

By MedXY|Nov 28, 2025

In a propensity‑matched Ontario cohort of women with chronic severe coronary artery disease, CABG was associated with lower long‑term MACCE and all‑cause mortality than PCI over a median 5.1 years.

Genetic Insights into LDL Cholesterol and Coronary Artery Disease Risk Across Diverse Global Populations
Cardiologycoronary artery diseasegenetics

Genetic Insights into LDL Cholesterol and Coronary Artery Disease Risk Across Diverse Global Populations

By MedXY|Oct 30, 2025

A large-scale multi-ancestry genetic study confirms consistent associations between LDL cholesterol levels and coronary artery disease risk across six global ancestries, highlighting the generalizability of LDL-C lowering interventions beyo

Revolutionizing Cardiac Rehab: The Impact of Wearable Technology and Online Coaching
AIcoronary artery diseaseremote monitoring

Revolutionizing Cardiac Rehab: The Impact of Wearable Technology and Online Coaching

By MedXY|Oct 23, 2025

This review discusses a landmark study demonstrating how wearable devices and online coaching improve exercise capacity in coronary artery disease patients, highlighting advancements in remote cardiac rehabilitation.

X-CircuiT versus Conventional Exercise in Home-Based Cardiac Rehabilitation: A Non-Inferiority Randomized Trial for CAD Patients
CardiologyPhục hồi chức năng timcoronary artery disease

X-CircuiT versus Conventional Exercise in Home-Based Cardiac Rehabilitation: A Non-Inferiority Randomized Trial for CAD Patients

By MedXY|Oct 23, 2025

This randomized controlled non-inferiority trial demonstrates that X-CircuiT, a smartphone-guided multi-component exercise regime, is as effective and safe as conventional exercise in improving fitness in home-based cardiac rehabilitation f

Clopidogrel versus Aspirin for Secondary Prevention in Coronary Artery Disease: A Comprehensive Meta-Analysis
CardiologyAntiplatelet TherapyAspirin

Clopidogrel versus Aspirin for Secondary Prevention in Coronary Artery Disease: A Comprehensive Meta-Analysis

By MedXY|Oct 11, 2025

This meta-analysis of nearly 29,000 CAD patients shows clopidogrel monotherapy reduces major cardiovascular events more than aspirin without increasing major bleeding risk, supporting clopidogrel as preferred secondary prevention.

Age-Stratified Outcomes of Rivaroxaban Monotherapy in Atrial Fibrillation with Stable Coronary Artery Disease: Insights from the AFIRE Trial
Clinical UpdatesAntithrombotic Therapyatrial fibrillation

Age-Stratified Outcomes of Rivaroxaban Monotherapy in Atrial Fibrillation with Stable Coronary Artery Disease: Insights from the AFIRE Trial

By MedXY|Sep 27, 2025

This post hoc AFIRE trial analysis shows rivaroxaban monotherapy reduces major cardiovascular events and major bleeding across age groups in AF with stable CAD, with notable age-related efficacy and safety trends warranting further research

Long-Term Survival Outcomes After Initial Stress Testing Versus Coronary CTA in Suspected CAD: Insights from the PROMISE Trial
Cardiologycoronary artery diseaseCoronary CTA

Long-Term Survival Outcomes After Initial Stress Testing Versus Coronary CTA in Suspected CAD: Insights from the PROMISE Trial

By MedXY|Oct 9, 2025

The PROMISE trial’s 10-year follow-up shows no difference in all-cause or cardiovascular mortality between initial functional stress testing and anatomic coronary CTA in symptomatic patients with suspected coronary artery disease.

Long-Term Outcomes of the DASH Intervention in Nonobstructive Coronary Artery Disease: Follow-Up of the DISCO-CT Study
Cardiologycardiovascular riskcoronary artery disease

Long-Term Outcomes of the DASH Intervention in Nonobstructive Coronary Artery Disease: Follow-Up of the DISCO-CT Study

By MedXY|Oct 8, 2025

A one-year DASH diet intervention led to sustained suppression of proatherogenic chemokine CXCL4 and fewer major cardiovascular events over six years despite reduced adherence and partial loss of initial benefits in nonobstructive CAD patie

Harnessing Machine Learning to Predict High-Risk Coronary Artery Disease: Insights from the SCOT-HEART Trial
AIComputed Tomography Angiographycoronary artery disease

Harnessing Machine Learning to Predict High-Risk Coronary Artery Disease: Insights from the SCOT-HEART Trial

By MedXY|Oct 7, 2025

Machine learning models trained on clinical data improve prediction of coronary artery disease on CT scans compared to traditional risk scores, potentially guiding better resource utilization in cardiovascular care.

Understanding Organ Calcification: When to Worry and What to Do
Cardiologycoronary artery diseasemedical imaging

Understanding Organ Calcification: When to Worry and What to Do

By MedXY|Oct 6, 2025

Discover the causes of organ calcification, differentiate harmless from dangerous types, and learn how to interpret your health reports with expert advice.

Clopidogrel Surpasses Aspirin: Comprehensive Meta-Analysis Shows Superior Secondary Prevention in Coronary Artery Disease
CardiologyAspirinclopidogrel

Clopidogrel Surpasses Aspirin: Comprehensive Meta-Analysis Shows Superior Secondary Prevention in Coronary Artery Disease

By MedXY|Oct 6, 2025

A large meta-analysis in The Lancet demonstrates that clopidogrel reduces MACCE risk by 14% over aspirin in CAD secondary prevention, with comparable safety over 5.5 years.

Comparative Effectiveness of Prasugrel Versus Clopidogrel in Patients with Impaired Renal Function: A Clinical Review
Cardiologyclopidogrelcoronary artery disease

Comparative Effectiveness of Prasugrel Versus Clopidogrel in Patients with Impaired Renal Function: A Clinical Review

By MedXY|Oct 4, 2025

Prasugrel demonstrates a more rapid and significant inhibition of platelet aggregation than clopidogrel in patients with stable coronary artery disease and impaired renal function, particularly within the first week of therapy.

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