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Elevated plasma p-tau217 correlates with cognitive impairment and altered sleep microarchitecture in older adults with late-onset unexplained epilepsy, highlighting potential pathways linking neurodegeneration, epilepsy severity, and sleep
This study explores how economic, educational, healthcare, neighborhood, and social factors link to multiple frailty dimensions in Chinese older adults, highlighting cognition as a key intermediary.
This study identifies distinct sleep patterns linked to cognitive performance but finds no significant direct association with dementia risk, highlighting the complexity of sleep-cognition relationships in aging populations.
This review synthesizes evidence on the long-term survival, excess mortality, and health-related quality of life in patients after chronic subdural hematoma surgery, emphasizing sustained mortality risks and cognitive-physical deficits up t
A long-term stroke study found that cognition improves most within 6 months, with memory and language recovering better than executive function. Early cognitive impairment was the strongest predictor of outcomes years later.
A multimodal translational study links genetically driven synaptic deficits in patient-derived neurons to cortical structure, electrophysiology, and cognition in schizophrenia, supporting biologically informed stratification of cognitive im
This study reveals that genetic predispositions interact with anticholinergic medication burden to influence cognitive deficits and brain gray matter volume reductions in psychosis spectrum disorders, offering new insights into personalized
Higher moderate-to-vigorous physical activity slows p-tau181 increase, a marker of Alzheimer’s pathology, but elevated p-tau181 diminishes exercise-related cognitive benefits in older adults.
A population-based study reveals that midlife exposure to air pollutants such as nitrogen dioxide and particulate matter is associated with cognitive decline and brain structural alterations by age 69-71, highlighting long-term neurological
This population-based study reveals that midlife exposure to nitrogen dioxide and particulate matter correlates with poorer cognitive function and adverse brain structural changes in later life, underscoring the neurocognitive risks of air
An 8-week cardiorespiratory exercise program initiated 2 months after ischemic stroke improved cognitive performance at 12 months, despite no significant preservation of hippocampal volume compared with control. The intervention was safe an
Regular walking and lifestyle interventions slow cognitive decline, especially in APOE ε4 carriers at heightened Alzheimer’s risk, with effects pronounced in women. Evidence underscores the value of simple activity and healthy diet for at-r
A large phase 3 trial reveals that structured, multidomain lifestyle interventions significantly improve cognition in older adults at risk for cognitive decline, outperforming self-guided strategies.
