Personalized Probiotic Therapy: Akkermansia muciniphila Supplementation in Overweight and Obese Type 2 Diabetes—Baseline Levels Matter

Highlights

• Metabolic benefit from Akkermansia muciniphila supplementation in overweight/obese type 2 diabetes (T2D) is dependent on baseline intestinal abundance of the bacterium.
• Individuals with low baseline A. muciniphila show significant improvements in weight, fat mass, and glycemic control after supplementation, while those with high baseline levels do not.
• Study underscores the potential of personalized, microbiota-guided probiotic interventions for metabolic diseases.

Study Background and Disease Burden