Obesity-Driven Left Atrial Remodeling in Atrial Fibrillation: Insights from Invasive Pressure-Volume Analysis

Highlight

1. Obesity is associated with significant left atrial (LA) enlargement and elevated LA pressures in patients with atrial fibrillation (AF), identified via invasive pressure-volume measurements.
2. BMI-related LA remodeling reflects a load-dependent adaptation without changes in LA stiffness.
3. LA strain measurements indicate early functional impairment despite preserved conventional volumetric indices.
4. Patients with concurrent heart failure (HF) demonstrate more severe remodeling, suggesting progression to atrial myopathy.

Study Background