Myocardial Fibrosis and Reverse Remodeling After Valve Replacement in Chronic Aortic Regurgitation: Advances and Clinical Implications
Highlights
- Advanced cardiac magnetic resonance (CMR) techniques identify both focal and diffuse myocardial fibrosis in chronic aortic regurgitation (AR) and predict post-AVR remodeling outcomes.
- AVR leads to significant left ventricular reverse remodeling characterized by reductions in LV end-diastolic volume (LVEDV), LV mass, and indexed extracellular volume, with cellular regression outpacing matrix regression.
- Focal myocardial scars quantified by late gadolinium enhancement (LGE) remain stable post-AVR and are independently associated with incomplete reverse remodeling.
- Despite structural improvements, objective functional capacity measured by maximal oxygen consumption may not substantially improve at early follow-up after AVR.
Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.