Intestinal Serotonergic Vagal Signaling: A Novel Link Between Gut Microbiota and Hypertension Management
Highlight
- Hypertension is influenced not only by cardiac and renal factors but also by gut microbiota through intestinal serotonergic signaling.
- Hypertensive rats and humans exhibit decreased intestinal serotonin (5-HT) levels and vagal 5HT3a receptor signaling activity.
- Fecal microbiota transplantation (FMT) from hypertensive rats decreases intestinal 5-HT and vagal signaling in normotensive rats, suggesting microbiota-driven modulation.
- Restoring 5HT3a receptor signaling in colonic vagal neurons alleviates hypertension, indicating a potential therapeutic target.
Study Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.