Impact of CYP2C19 Polymorphisms on Medical and Surgical Management of GERD: Implications for Personalized Therapy
Highlight
- Proton pump inhibitor (PPI) effectiveness in GERD is significantly influenced by CYP2C19 genetic polymorphisms affecting drug metabolism.
- Surgically treated patients with GERD exhibit a higher prevalence of CYP2C19 rapid and ultrarapid metabolizer phenotypes compared to medically managed patients.
- CYP2C19 testing could guide PPI dose adjustments and early surgical referral to optimize GERD management outcomes.
- This study is among the first to demonstrate the clinical utility of pharmacogenomic profiling in adult GERD treatment strategies.
Study Background
MedXY registered readers
Sign in free to continue reading
Create or use your MedXY account to unlock the complete article.
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.