Highlight
1. Obesity is independently associated with increased risk of solid organ, central nervous system (CNS), and skin subsequent neoplasms in childhood cancer survivors.
2. Higher physical activity levels correlate with a significantly reduced risk of developing subsequent neoplasms.
3. Combined lifestyle factors such as BMI and exercise may influence the development of specific subsequent neoplasm types like meningiomas and thyroid carcinomas.
4. Lifestyle interventions represent a promising avenue for secondary cancer prevention in this high-risk population.
