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Exploring the Impact of Body Mass Index on Heart Failure Outcomes: Insights from Mendelian Randomization
CardiologyBody Mass Indexcardiovascular outcomes

Exploring the Impact of Body Mass Index on Heart Failure Outcomes: Insights from Mendelian Randomization

By MedXY|Jun 10, 2026

This study leverages Mendelian randomization to demonstrate that genetically elevated BMI is associated with increased mortality and adverse cardiovascular outcomes in heart failure, irrespective of ejection fraction status, underscoring po

Body Mass Index, Clinical Outcomes, and Mortality in Heart Failure: A Mendelian Randomization Study
CardiologyBody Mass Index
cardiovascular outcomes

Body Mass Index, Clinical Outcomes, and Mortality in Heart Failure: A Mendelian Randomization Study

By MedXY|Jun 10, 2026

This study uses Mendelian randomization to show that higher genetically predicted BMI is associated with increased all-cause mortality and cardiovascular events in heart failure patients, regardless of ejection fraction status.

Midlife Central Obesity Tracks With Higher Late-Life Plasma P-tau217 and Biomarker-Verified Alzheimer Dementia, While the Association Reverses in Old Age
NeurologyAlzheimer diseaseBody Mass Index

Midlife Central Obesity Tracks With Higher Late-Life Plasma P-tau217 and Biomarker-Verified Alzheimer Dementia, While the Association Reverses in Old Age

By MedXY|Jun 3, 2026

In the HUNT Study, higher midlife waist-to-height ratio and BMI predicted higher late-life plasma p-tau217 and biomarker-verified Alzheimer dementia, whereas higher adiposity in late life was associated with lower biomarker levels and lower

Genetic Evidence Strengthens High BMI as a Causal Driver of Vascular Dementia, With Blood Pressure as a Partial Mediator
Diabetes & EndocrinologyBody Mass IndexHypertension

Genetic Evidence Strengthens High BMI as a Causal Driver of Vascular Dementia, With Blood Pressure as a Partial Mediator

By MedXY|Jun 3, 2026

A 2026 Mendelian randomization study supports high BMI as a causal risk factor for vascular-related dementia, with part of the effect mediated through elevated systolic and diastolic blood pressure.

In Transition-Age Childhood-Onset GH Deficiency, Glucagon Test Results Reflect Pituitary Damage More Than Body Mass Index
Diabetes & EndocrinologyBody Mass Indexglucagon stimulation test

In Transition-Age Childhood-Onset GH Deficiency, Glucagon Test Results Reflect Pituitary Damage More Than Body Mass Index

By MedXY|May 31, 2026

In 180 adolescents and young adults with childhood-onset GH deficiency, glucagon-stimulated GH secretion was driven mainly by hypothalamic-pituitary disease severity, while BMI had little independent effect after accounting for etiology.

Weight Trajectories Among Youths Following Residential Relocation
newsair pollutionBody Mass Index

Weight Trajectories Among Youths Following Residential Relocation

By MedXY|Nov 19, 2025

This study explores how changes in residential environments affect childhood BMI, focusing on air pollution, built environment, and socioeconomic factors across cohorts in the Netherlands, Sweden, and Czech Republic.

Impact of BMI and Physical Activity on Subsequent Neoplasm Risk in Childhood Cancer Survivors: Insights from the CCSS Cohort
OncologyBody Mass IndexChildhood Cancer Survivors

Impact of BMI and Physical Activity on Subsequent Neoplasm Risk in Childhood Cancer Survivors: Insights from the CCSS Cohort

By MedXY|Oct 4, 2025

Obesity increases, while higher physical activity decreases, risk of subsequent neoplasms among childhood cancer survivors, highlighting lifestyle intervention potential for cancer prevention.

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