Harnessing Genetic Insights: Polygenic Risk Score Enhances Prediction of Peripheral Artery Disease and Limb Events

Highlight

• A recently validated polygenic risk score (PRS) is independently associated with prevalent peripheral artery disease (PAD) and incidence of major adverse limb events (MALE) in cardiometabolic patients.
• Each standard deviation increase in PRS confers a 15% higher odds of prevalent PAD and a 30% increased risk of MALE, comparable to established clinical risk factors.
• Incorporating the PAD PRS with clinical variables modestly improves risk discrimination for MALE but may have limited immediate clinical utility.

Study Background