Guideline‑Level Moderate–Vigorous Physical Activity Appears Safe and Beneficial for Phenotype‑Negative Car cardiomyopathy Variant Carriers

Highlights

Key points

– In 84,699 UK Biobank participants (3,979 G+P- carriers) with 1‑week accelerometer data and 8 years median follow-up, higher moderate‑to‑vigorous physical activity (MVPA) was associated with lower incidence of atrial fibrillation (AF), heart failure (HF), myocardial infarction (MI), and stroke, regardless of genotype.
– For G+P- carriers, MVPA of roughly 100–400 minutes per week associated with the lowest risk estimates for major cardiovascular outcomes; hazard ratios (HRs) vs zero activity included AF 0.68 (95% CI 0.58–0.79), HF 0.58 (0.47–0.71), MI 0.49 (0.24–1.00), and stroke 0.35 (0.12–0.99).
– CMR indices of cardiac remodeling (LV size and LV mass) showed similar relationships with MVPA in carriers and noncarriers. Higher MVPA was not associated with increased risk of malignant ventricular arrhythmias (VAs) in G+P- carriers.