Epigenetic Silencing of Hepatocyte FoxO1: A Novel Mechanism Disrupting Liver Immune Balance and Driving Inflammation
Highlight
- Hepatocyte FoxO1 expression is epigenetically repressed via JMJD1C-regulated histone H3K9 dimethylation during liver inflammation.
- Loss of FoxO1 in hepatocytes disrupts local immune homeostasis by altering NKT cell apoptosis and promoting neutrophil accumulation.
- FoxO1 induces hepatocyte CD1d expression through retinoic acid synthesis, a critical pathway for controlling NKT cells.
- Targeting the FoxO1-JMJD1C-CD1d axis offers a novel therapeutic avenue for inflammatory liver diseases such as alcoholic hepatitis and hepatic schistosomiasis.
Study Background
MedXY registered readers
Sign in free to continue reading
Create or use your MedXY account to unlock the complete article.
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.