Distinct Myeloid Landscapes Define Prognostic Niches in Extranodal NK/T-Cell Lymphoma
Highlight
- ENKTL exhibits two distinct myeloid-defined subgroups characterized by inflammatory or immune-quiescent macrophage programs.
- An NF-κB-activated, EBV-associated tumor subset colocalizes with inflammatory macrophages, forming a prognostic inflammatory niche.
- Tumor-myeloid cooperativity involves CCL- and IL1-mediated myeloid recruitment and self-reinforcement within the lymphoma microenvironment.
- The abundance of this inflammatory niche correlates with improved survival, offering insights for targeted immunotherapeutic strategies.
Study Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.