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Comparative Effects of Nicorandil, Isosorbide Mononitrate, and Diltiazem on Radial Artery Graft Patency After CABG: Insights from the ASRAB-Pilot Trial

MedXY Editorial Team•Oct 3, 2025•Cardiology
CABGgraft failurenicorandil

Highlight

  • Nicorandil and isosorbide mononitrate treatment post-CABG associated with lower radial artery (RA) graft failure rates than diltiazem at 24 weeks.
  • At 1 week post-surgery, nicorandil and isosorbide mononitrate showed trends toward reduced graft failure compared to diltiazem, though differences were not statistically significant.
  • This pilot randomized trial provides important comparative data to guide selection of antispastic agents after CABG with RA grafts.
  • Larger hypothesis-testing trials are necessary to validate these encouraging findings and inform clinical guidelines.

Study Background and Disease Burden

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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

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