Challenges in Using Insulin Dose-Adjusted HbA1c to Identify Partial Remission in Pediatric Type 1 Diabetes: Insights from the SEARCH for Diabetes in Youth Study
Highlight
1. Insulin dose-adjusted hemoglobin A1c (IDAA1c) ≤9 is commonly used to define partial remission in pediatric type 1 diabetes but has not been validated for U.S. youth.
2. The SEARCH for Diabetes in Youth study revealed that IDAA1c ≤9 underestimates β-cell function, particularly in youth with overweight or obesity.
3. Higher BMI increases insulin resistance and insulin requirements, reducing IDAA1c’s sensitivity to detect partial remission.
4. Adjusting IDAA1c cutoffs for BMI categories improved sensitivity but reduced specificity in identifying partial remission.
Study Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.