
医学资讯JOSD1PGAM1
肝细胞癌中代谢重编程的解耦:JOSD1-PGAM1 泛素化-乳酰化开关
By MedXY|2026年5月1日
本文探讨了去泛素化酶 JOSD1 如何通过调节 PGAM1 上的新 PTM 开关促进 HCC 进展,增强糖酵解和免疫逃逸,并提供了一个新的联合免疫治疗靶点。
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