
医学资讯BCR信号通路ibrutinib耐药
靶向CLL中的MERTK:克服ibrutinib耐药的潜在新策略
By MedXY|2026年9月29日
MERTK在CLL中可通过CD79a异常激活BCR信号,提示其为新的治疗靶点。抑制MERTK的UNC-2025对ibrutinib耐药复发具有潜在疗效,尤其与venetoclax联用时更为突出。
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