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A 12-week randomized trial explored sleep optimization in adults with type 1 diabetes, revealing improved sleep quality and reduced diabetes distress but limited glycemic benefits except in patients with baseline A1C ≥7%.
A pooled individual participant data meta-analysis demonstrates that Electromagnetic Network-Targeted Field (ENTF) neuromodulation significantly improves freedom-from-disability and reduces poststroke disability compared to sham treatment,
A 2026 RCT assessed telehealth stepped alcohol treatment in chronic liver disease patients, finding significant reductions in weekly alcohol consumption but no difference in achieving moderate drinking levels compared to usual care.
A multicenter RCT shows proactive home fecal calprotectin monitoring without protocolized treatment escalation does not reduce symptomatic flares in ulcerative colitis remission. More research is needed to optimize biomarker-guided manageme
A 2026 PLOS One superiority trial found that internet-based vestibular rehabilitation was not superior to structured written instructions after acute vertigo. The result is clinically useful because the comparator was active, adherence was
Recent high-quality randomized clinical trials and meta-analyses suggest that routine magnesium sulfate infusion does not effectively prevent postoperative atrial fibrillation in cardiac surgery, especially when used alongside standard beta
In mild-to-moderate acute cholangitis, ERCP within 24 hours did not improve mortality or organ-failure outcomes versus ERCP within 24–48 hours, and it was linked to more procedure-related adverse events.
A randomized trial found vaginal assisted NOTES hysterectomy improved same-day discharge, operative time, and blood loss versus standard vaginal hysterectomy, without increasing complications or affecting recovery.
A randomized trial in high-risk adults with type 2 diabetes found that proactive nurse-led care reduced severe hypoglycemia by about 50%, while adding psychoeducation did not significantly improve outcomes further.
A randomized trial found that 6 hours of intrauterine balloon tamponade was noninferior to 18 hours for controlling postpartum hemorrhage after vaginal delivery, suggesting earlier removal may be reasonable in stable patients.
The FreeDM2 trial demonstrates that real-time CGM significantly improves HbA1c levels compared to SMBG in adults with type 2 diabetes on basal insulin and modern therapies, with sustained benefits over 32 weeks.
A recent randomized controlled trial demonstrates that proximal hypoglossal nerve stimulation significantly improves obstructive sleep apnea symptoms in patients intolerant to positive airway pressure therapy.
The TREOCAPA randomized clinical trial demonstrates that while prophylactic intravenous acetaminophen effectively promotes patent ductus arteriosus closure in extremely preterm infants, it does not significantly increase survival without se
The NAPSACC UK cluster RCT found that a one-year environmental intervention in early childhood education settings did not significantly improve total energy consumption or physical activity, highlighting the need for broader policy-level ch
The SCIENCE multicentre randomized trial demonstrates that surgical fixation for displaced medial epicondyle fractures in children provides no functional advantage over non-surgical care, carries higher complication risks, and is not a cost
A 6-month randomized controlled trial reveals that varying dietary sweet taste exposure does not alter sweet taste liking, energy intake, or body weight, questioning the efficacy of public health recommendations to reduce sweet exposure for
Integrating tailored adherence support into exercise rehabilitation for vertebral fragility fractures significantly improves functional mobility and walking capacity compared to standard exercise alone at 12 months.
A large RCT in primary care showed no significant cognitive benefits of a combined intervention integrating mind-body physical exercise, cognitive training, and nurse-led risk factor modification over nurse-led risk factor modification alon
A large randomized controlled trial found that an Iyengar yoga-based exercise program increased fall rates among older adults compared to seated relaxation yoga, despite improvements in physical activity and balance confidence, highlighting
This study finds no significant benefit of the Circle of Security-Parenting intervention added to usual care for improving mental health and bonding among new parents in NHS settings.
