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Timing of Initiation of Methadone Take-Home Dosing: Evidence Synthesis and Clinical Implications for Opioid Use Disorder Management
Anesthesiologyopioid use disordertreatment retention

Timing of Initiation of Methadone Take-Home Dosing: Evidence Synthesis and Clinical Implications for Opioid Use Disorder Management

By MedXY|Sep 17, 2026

Early initiation of methadone take-home dosing (5-24 weeks post-induction) reduces mortality and treatment discontinuation, surpassing benefits seen with no take-home dosing. Flexible dosing policies improve retention without increasing ove

Receipt of Pharmacotherapy and Healthcare Utilization Among US Adults with Alcohol or Opioid Use Disorder: Insights from 2022-2023 National Data
Clinical Updates
opioid use disorder
substance use disorder

Receipt of Pharmacotherapy and Healthcare Utilization Among US Adults with Alcohol or Opioid Use Disorder: Insights from 2022-2023 National Data

By MedXY|Sep 3, 2026

Few US adults with alcohol or opioid use disorder reported addiction pharmacotherapy use in 2022-2023. Pharmacotherapy receipt was linked to increased healthcare utilization, underscoring the need for early outpatient intervention strategie

Association Between Opioid Use Disorder and Hysterectomy Outcomes: A Comprehensive Clinical Review
Anesthesiologyhysterectomy outcomesopioid use disorder

Association Between Opioid Use Disorder and Hysterectomy Outcomes: A Comprehensive Clinical Review

By MedXY|Aug 18, 2026

Patients with opioid use disorder (OUD) face higher postoperative complications, longer inpatient stays, and increased costs following hysterectomy. This review synthesizes clinical evidence and explores implications for surgical management

Predicting Opioid Use Disorder and Overdose Risk in Older Adults: Evaluating Prognostic Models
Internal Medicinechronic painolder adults

Predicting Opioid Use Disorder and Overdose Risk in Older Adults: Evaluating Prognostic Models

By MedXY|Jul 21, 2026

This study develops and compares predictive models incorporating claims and patient-reported data to forecast time to first opioid use disorder (OUD) or overdose (OD) among older adults with chronic pain on opioids, identifying key risk fac

Why an EHR-Embedded OUD Intervention Still Struggled: Lessons from 12 Colorado Hospitals
newselectronic health recordKhoa học Triển khai

Why an EHR-Embedded OUD Intervention Still Struggled: Lessons from 12 Colorado Hospitals

By MedXY|Jun 19, 2026

A qualitative study across 12 Colorado hospitals found that an EHR-embedded OUD intervention improved awareness but still faced stigma, inconsistent messaging, limited addiction expertise, and workflow barriers to MOUD initiation.

Health Plan Disenrollment and Mortality After Starting Medications for Opioid Use Disorder
newsbuprenorphinehealth insurance

Health Plan Disenrollment and Mortality After Starting Medications for Opioid Use Disorder

By MedXY|May 23, 2026

A large cohort study found that health plan disenrollment after starting buprenorphine or naltrexone for opioid use disorder was linked to higher all-cause and overdose mortality, highlighting the importance of continuous coverage and treat

Extended-Release vs Sublingual Buprenorphine in Pregnancy Through 12 Months Post Partum: A Randomized Clinical Trial
OB/GYN & Women's Healthmaternal healthPregnancy

Extended-Release vs Sublingual Buprenorphine in Pregnancy Through 12 Months Post Partum: A Randomized Clinical Trial

By MedXY|Aug 18, 2026

A clinical trial found that weekly extended-release buprenorphine significantly improves illicit opioid abstinence during pregnancy compared to sublingual forms, with fewer serious adverse events, offering a safer treatment option for opioi

Injectable vs. Sublingual Buprenorphine: Shaping the Future of Emergency OUD Care
Emergency Medicinebuprenorphineclinical trial

Injectable vs. Sublingual Buprenorphine: Shaping the Future of Emergency OUD Care

By MedXY|Feb 22, 2026

The ED INNOVATION trial reveals that 7-day extended-release injectable buprenorphine is safe and as effective as sublingual formulations for treatment engagement, offering significant benefits in craving reduction and patient satisfaction e

The 400 Percent Transit Penalty: How Travel Barriers Systemically Restrict Methadone Access
newskhả năng tiếp cận chăm sócmethadone

The 400 Percent Transit Penalty: How Travel Barriers Systemically Restrict Methadone Access

By MedXY|Feb 6, 2026

A geospatial analysis in Connecticut reveals that patients relying on public transit face travel times nearly four times longer than those with cars, with over 50% of areas lacking viable transit to methadone clinics, highlighting an urgent

The Limits of Collaborative Care: Why the CLARO Trial Found No Added Benefit for OUD and Comorbid Mental Illness
Internal Medicinecollaborative caredepression

The Limits of Collaborative Care: Why the CLARO Trial Found No Added Benefit for OUD and Comorbid Mental Illness

By MedXY|Jan 1, 2026

The CLARO randomized clinical trial investigated whether a collaborative care model could improve outcomes for patients with opioid use disorder and co-occurring depression or PTSD. The study found no statistically significant advantages ov

Optimizing Opioid Use Disorder Treatment: When Does 300 mg Outperform 100 mg of Extended-Release Buprenorphine?
newsbuprenorphinefentanyl

Optimizing Opioid Use Disorder Treatment: When Does 300 mg Outperform 100 mg of Extended-Release Buprenorphine?

By MedXY|Dec 21, 2025

This randomized clinical trial compares 100-mg and 300-mg maintenance doses of extended-release buprenorphine. While overall efficacy was similar, the 300-mg dose significantly improved abstinence among patients with high-frequency fentanyl

High-Dose Extended-Release Buprenorphine: A Targeted Strategy for the Fentanyl-Driven Opioid Crisis
newsbuprenorphinefentanyl

High-Dose Extended-Release Buprenorphine: A Targeted Strategy for the Fentanyl-Driven Opioid Crisis

By MedXY|Dec 20, 2025

This randomized clinical trial compares 100-mg versus 300-mg maintenance doses of extended-release buprenorphine. While overall efficacy was similar, the 300-mg dose significantly improved abstinence rates among heavy fentanyl users, offeri

Collaborative Care for OUD in Primary Care Reduces Opioid Use: Cluster RCT Shows Added Benefit from an OUD-Focused Model
Family Medicine & Nutritioncollaborative careopioid use disorder

Collaborative Care for OUD in Primary Care Reduces Opioid Use: Cluster RCT Shows Added Benefit from an OUD-Focused Model

By MedXY|Nov 14, 2025

A pragmatic cluster randomized trial found that adding OUD-specific components to collaborative care in primary care clinics reduced days of opioid use more than collaborative care for mental health alone, without clear additional mental he

Treatment Retention in Opioid Use Disorder During Pregnancy: Buprenorphine vs Methadone Discontinuation Patterns
newsbuprenorphinemethadone

Treatment Retention in Opioid Use Disorder During Pregnancy: Buprenorphine vs Methadone Discontinuation Patterns

By MedXY|Oct 30, 2025

This nationwide cohort study reveals higher discontinuation rates of buprenorphine than methadone during pregnancy and up to one year postpartum, highlighting significant challenges in treatment retention for opioid use disorder in pregnant

Hospital Addiction Consult Services: A Promising Step to Reduce Emergency Visits Among Patients with Opioid Use Disorder
newsMortalityopioid use disorder

Hospital Addiction Consult Services: A Promising Step to Reduce Emergency Visits Among Patients with Opioid Use Disorder

By MedXY|Oct 7, 2025

A hospital-based addiction consult program lowered emergency department visits in opioid use disorder patients but did not reduce hospitalizations or mortality, highlighting the need for comprehensive care beyond hospital walls.

Evaluating the Role of Behavioral Therapy in Enhancing Buprenorphine Treatment Outcomes for Opioid Use Disorder: Insights from a Secondary Analysis of Four Randomized Clinical Trials
PsychiatryBehavioral therapybuprenorphine

Evaluating the Role of Behavioral Therapy in Enhancing Buprenorphine Treatment Outcomes for Opioid Use Disorder: Insights from a Secondary Analysis of Four Randomized Clinical Trials

By MedXY|Oct 7, 2025

A secondary analysis of four randomized trials reveals that additional behavioral therapy does not significantly improve opioid abstinence, retention, or functional outcomes when added to buprenorphine and medical management in opioid use d

Enhancing Opioid Use Disorder Care in Primary Settings: Impact of an EHR-Integrated Clinical Decision Support System
Clinical Updatesclinical decision support systemopioid use disorder

Enhancing Opioid Use Disorder Care in Primary Settings: Impact of an EHR-Integrated Clinical Decision Support System

By MedXY|Oct 7, 2025

A cluster randomized trial demonstrates that an electronic health record–integrated clinical decision support system increases naloxone prescriptions and opioid use disorder treatments in primary care but does not change diagnosis rates or

Synthetic Opioid Overdose Deaths Among Youth Surge 168%: A Five-Year Analysis and Clinical Implications
Clinical Updatesfentanylharm reduction

Synthetic Opioid Overdose Deaths Among Youth Surge 168%: A Five-Year Analysis and Clinical Implications

By MedXY|Sep 30, 2025

Overdose deaths from synthetic opioids alone in U.S. youth aged 15–24 surged 168% between 2018 and 2022, now representing one-third of all youth OD fatalities. Clinical vigilance, harm reduction, and targeted prevention are urgently needed.

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