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A landmark study of over 18,000 patients reveals that sarcoidosis incidence and prevalence in England are rising, particularly among older adults. With a 36% higher mortality risk compared to the general population, these findings demand a
A large-scale multicenter study reveals that hospitals with higher utilization rates of continuous kidney replacement therapy (CKRT) achieve significantly lower 90-day mortality for critically ill AKI patients compared to low-utilization ce
A systematic review and meta-analysis found early enteral nutrition (EEN) in critically ill children associated with lower mortality (adjusted OR 0.36) and improvements in several clinical outcomes, but evidence certainty is very low due to
A 2007–2019 National Trauma Data Bank analysis found ARDS incidence among ventilated trauma patients fell substantially, yet ARDS remained independently associated with increased 30‑day mortality and crude ARDS mortality rose to nearly 30%.
A multinational time-series study across nine countries found increased short-term mortality after tropical cyclones for multiple causes — highest for renal disease and injuries — with larger effects in deprived and cyclone-naïve communitie
In a population-based Alberta cohort, women with incident stage 5 CKD lost the usual female survival advantage: younger women had substantially higher excess mortality than men and were less likely to receive transplants or dialysis, indepe
A retrospective MIMIC‑IV cohort presented at AHA 2025 found perioperative metformin exposure in T2DM patients undergoing cardiac surgery associated with markedly lower 30‑, 90‑ and 360‑day mortality. Results are compelling but observational
A pooled analysis of three population cohorts shows lean MASLD carries higher risks of liver-related events and all-cause and liver-related mortality despite lower cardiovascular event risk compared with non-lean MASLD.
An international study reveals that postoperative vasopressor infusions after noncardiac surgery vary widely across hospitals and are linked to higher mortality and complications, highlighting the need for optimized management strategies.
This study reveals that both low and high ambient temperatures significantly increase mortality risk among Swedish heart failure patients, highlighting the need for climate adaptation strategies in high-latitude regions.
This study highlights how poor mental well-being during adolescence predicts increased risks of mental illness, risky behaviors, and mortality in young adulthood, emphasizing the urgency for early identification and intervention.
This study compares long-acting injectable to oral antipsychotics in older schizophrenia patients, highlighting benefits in relapse prevention and mortality reduction, with specific considerations for adverse effects.
This meta-analysis reveals that short-term mortality in severe alcohol-associated hepatitis remains high, with no significant improvement over the past four decades despite advances in care, underscoring the urgent need for better therapies
This article reviews findings from the CLOVERS trial analyzing endothelial glycocalyx degradation in sepsis, demonstrating its strong association with mortality but showing no impact of liberal versus restrictive fluid resuscitation strateg
A causal analysis of nine dietary patterns reveals the Mediterranean diet as most effective in reducing all-cause and cardiovascular mortality, primarily through modulation of inflammatory biomarkers such as CRP, NPR, and SII.
A hospital-based addiction consult program lowered emergency department visits in opioid use disorder patients but did not reduce hospitalizations or mortality, highlighting the need for comprehensive care beyond hospital walls.
Kidney tubular damage biomarkers independently predict death and heart failure readmission in acute heart failure, highlighting novel risk stratification beyond traditional glomerular measures.
Higher adherence to an anti-inflammatory diet is linked to lower all-cause mortality and a trend toward reduced Alzheimer’s disease mortality, particularly among men and non-Hispanic Whites, highlighting dietary modification as a pote
A nationwide Danish study reveals that while 40% of left-sided infective endocarditis patients have surgical indications, only half undergo surgery. Those receiving surgery are younger, less comorbid, and show improved survival, underscorin
Recent research reveals a U-shaped relationship between exercise and biological aging, showing that moderate exercise slows aging best, while inactivity or excessive exercise may accelerate it.
