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The CHOICE trial investigated whether hearing aid intervention reduces dementia progression in older adults with mild cognitive impairment and hearing loss, finding no significant reduction in dementia incidence but increased cognitive impr
Baseline cortical atrophy within an EOAD-specific brain signature predicts progression from mild cognitive impairment to dementia, providing a valuable MRI biomarker for individualized prognosis in early-onset Alzheimer disease.
This review evaluates a recent 2-year pilot RCT on low-dose lithium carbonate for MCI, synthesizing its findings with emerging evidence on Aβ clearance, gut-brain axis modulation, and multimodal disease forecasting.
This pilot randomized clinical trial investigated low-dose lithium for Mild Cognitive Impairment (MCI). While primary outcomes regarding cognition and neuroimaging were not statistically significant, the study established the intervention&#
In an ADNI longitudinal cohort, persistently elevated depressive symptoms over 36 months after MCI diagnosis were associated with a dose‑dependent, substantially higher hazard of conversion to Alzheimer’s disease over long-term follow-up.
A large RCT in primary care showed no significant cognitive benefits of a combined intervention integrating mind-body physical exercise, cognitive training, and nurse-led risk factor modification over nurse-led risk factor modification alon
This review synthesizes evidence on clinically meaningful within-patient changes in cognitive and functional assessments among individuals transitioning to mild cognitive impairment (MCI), highlighting implications for clinical trials and e
A 24-week randomized, double-blind trial shows sodium benzoate, a D-amino acid oxidase inhibitor, improves short-term memory in patients with amnestic mild cognitive impairment, suggesting a potential therapeutic role with a favorable safet
A 36-week study shows that dapagliflozin significantly improves cognitive function and metabolic parameters in middle-aged and older patients with type 2 diabetes and mild cognitive impairment.
