Clinically Meaningful Changes in Cognitive and Functional Measures Early in Alzheimer’s Disease: Insights from Population-Based Cohorts
Highlights
- Population-based studies reveal specific thresholds of meaningful within-patient change on commonly used clinical outcome assessments (COAs) in early cognitive impairment.
- Annualized change thresholds for CDR scale Sum of Boxes (0.49), MMSE (-1.01), and FAQ (1.04) in incident MCI offer benchmarks for interpreting clinical progression.
- These data enhance clinical trial planning and evaluation by anchoring COA changes to clinically meaningful functional and cognitive decline early in ADRD.
- Mechanistic insights into neurodegeneration underscore the importance of early detection and targeted interventions based on changes in cognition and function.
Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.