Low-Dose Lithium for Mild Cognitive Impairment: A Pilot Randomized Clinical Trial and Synthesis of Emerging Neuroprotective Paradigms
Highlights
- A 2-year pilot RCT (PMID: 41770546) suggests that low-dose lithium carbonate is feasible and safe for older adults with Mild Cognitive Impairment (MCI).
- While primary outcomes did not reach significance, a trend toward slower decline in verbal memory (CVLT-II) was observed (P = .05), suggesting a potential cognitive signal.
- Lithium’s role is being re-evaluated alongside emerging disease-modifying therapies like lecanemab and novel multisystem targets such as GPR3 and the gut-brain axis.
- Advanced machine learning and multimodal modeling (PMID: 41376794) are essential for identifying MCI subgroups likely to benefit from neuroprotective agents like lithium.
Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.