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A post-hoc analysis of the ACCORD trial reveals that intensive blood pressure control significantly reduces cardiovascular and stroke risk in haptoglobin 1 allele carriers, but not in those with the Hp2-2 phenotype, suggesting a genotype-dr
A landmark Swedish cohort study demonstrates that diabetes subgroups, particularly those characterized by insulin resistance and deficiency, carry significantly higher risks for end-organ damage and cardiovascular mortality than previously
A large-scale meta-analysis reveals that lowering blood pressure in patients with isolated diastolic hypertension (IDH) provides cardiovascular protection comparable to those with systolic elevations, suggesting that diastolic thresholds al
A large-scale UK Biobank study demonstrates that combining NMR metabolomics and polygenic risk scores with the SCORE2 framework significantly improves cardiovascular risk discrimination, potentially doubling the number of preventable events
Recent large-scale studies demonstrate that high-sensitivity C-reactive protein (hsCRP) is a potent, stable predictor of cardiovascular events, even in individuals without traditional risk factors. Despite its clinical utility in improving
A large-scale cohort study from the Western Denmark Heart Registry demonstrates that high LDL-C remains a significant predictor of non-calcified plaque and coronary heart disease events in patients with a CAC score of zero, particularly amo
A large-scale cohort study demonstrates that delaying statin therapy following the incidental discovery of high LDL-C during routine health screenings leads to a progressively higher risk of myocardial infarction, emphasizing the critical i
Recent evidence reveals that COPD in adults under 50 is more prevalent than previously thought, significantly increasing the risk of premature death and heart failure. Furthermore, impaired lung function trajectories starting in childhood p
AI-driven analysis of routine chest CTs reveals that coronary artery calcium is highly prevalent and strongly predictive of MACE and mortality in patients with IMIDs, identifying a critical treatment gap in this high-risk population.
A prospective ARIC cohort study reveals that diabetes fundamentally modifies the relationship between the triglyceride-glucose (TyG) index and subclinical myocardial injury, shifting the risk profile from an L-shaped to a J-shaped associati
A post hoc analysis of the STOP-or-NOT trial demonstrates that preoperative cardiovascular risk stratification does not influence the outcomes of continuing versus discontinuing renin-angiotensin system inhibitors before major noncardiac su
Updated Cochrane review shows mixed outcomes for long-term hormone therapy in peri- and postmenopausal women.
A large retrospective cohort study shows traumatic spinal cord injury (TSCI) is associated with increased long-term cardiovascular, neurologic, psychiatric, and endocrine morbidity and higher mortality, even in previously healthy adults.
This review synthesizes evidence on the performance of AHA PREVENT equations in individuals with elevated lipoprotein(a), emphasizing its independent risk association and potential to enhance personalized ASCVD risk prediction.
A multinational cross-sectional study of 1003 people with antiphospholipid syndrome (APS) found high prevalence of hypertension, hyperlipidaemia, obesity and smoking, with suboptimal attainment of guideline targets — particularly among thos
Genetic predisposition to preeclampsia and gestational hypertension is associated with higher risk of later-life cardiovascular disease; polygenic risk amplifies this risk, while obstetric history improves risk stratification beyond PRSs al
A large Dutch cohort study found that after adjusting for socioeconomic status and lifestyle, transgender women on oestradiol had lower myocardial infarction (MI) risk but higher venous thromboembolism (VTE) risk; transgender men on testost
New animal research links oral microplastic exposure to dramatic increases in arterial plaque—especially in males—by injuring endothelial cells and provoking inflammation and oxidative stress.
The GBD 2023 analysis estimates 788 million adults living with chronic kidney disease in 2023, rising since 1990, with CKD a top-10 cause of death and a major contributor to cardiovascular mortality. Urgent action on screening, prevention,
In >13,000 older women followed ≈11 years, achieving ≥4,000 steps on as little as 1–2 days/week was linked to lower all‑cause mortality and CVD; higher daily step thresholds produced additional benefit, but associations were driven large
