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Evaluating Vericiguat in Coronary Vasospasm: Insights from the ViVA Randomized Cross-Over Trial
CardiologyvericiguatCoronary Vasospasm

Evaluating Vericiguat in Coronary Vasospasm: Insights from the ViVA Randomized Cross-Over Trial

By MedXY|Sep 8, 2026

This article reviews the ViVA trial assessing vericiguat, an sGC stimulator, in angina patients with coronary vasospasm but no obstructive coronary artery disease. The study found no significant improvement in vasodilator function or angina

Long-Term Benefits of Surgical Unroofing in Angina Patients with Myocardial Bridge and Non-Obstructive Coronary Arteries
CardiologyanginaMyocardial Bridge

Long-Term Benefits of Surgical Unroofing in Angina Patients with Myocardial Bridge and Non-Obstructive Coronary Arteries

By MedXY|Aug 15, 2026

Surgical unroofing significantly improves long-term symptoms and quality of life in patients with symptomatic myocardial bridge and non-obstructive coronary arteries refractory to medical therapy.

Determining the Physiological Threshold for Angina (ORBITA-FIRE): A Double-Blind, Randomized, Placebo-Controlled Study
CardiologyanginaCardiology

Determining the Physiological Threshold for Angina (ORBITA-FIRE): A Double-Blind, Randomized, Placebo-Controlled Study

By MedXY|Jun 10, 2026

ORBITA-FIRE shows that angina occurs at much lower, individualized FFR and RFR thresholds than standard ischemia cutoffs, and these thresholds rise with exercise intensity.

Determining the Physiological Threshold for Angina (ORBITA-FIRE): A Double-Blind, Randomized, Placebo-Controlled Study
CardiologyanginaFFR

Determining the Physiological Threshold for Angina (ORBITA-FIRE): A Double-Blind, Randomized, Placebo-Controlled Study

By MedXY|May 9, 2026

ORBITA-FIRE study reveals personalized physiological thresholds for angina that are lower than current diagnostic standards. These thresholds vary during exercise and predict PCI treatment success, challenging universal ischemia-based guide

Quality of Life After Percutaneous Coronary Intervention or Medical Therapy for Chronic Total Coronary Occlusions: EUROCTO and DECISION-CTO Meta-Analysis
Cardiologyanginachronic total occlusion

Quality of Life After Percutaneous Coronary Intervention or Medical Therapy for Chronic Total Coronary Occlusions: EUROCTO and DECISION-CTO Meta-Analysis

By MedXY|Apr 13, 2026

A pooled analysis of EUROCTO and DECISION-CTO trials found PCI significantly improved quality of life, angina frequency, and SAQ scores compared to medical therapy for patients with chronic total coronary occlusions, with no increased risk

Persistent Healthcare Burden in Women with Chest Pain Despite No Obstructive Coronary Artery Disease: Insights from the WOMANOCA Study
CardiologyanginaCardiology

Persistent Healthcare Burden in Women with Chest Pain Despite No Obstructive Coronary Artery Disease: Insights from the WOMANOCA Study

By MedXY|Jan 4, 2026

A nationwide Danish cohort study reveals that women with angina or non-specific chest pain and no obstructive coronary artery disease face significantly higher rates of cardiac readmissions and primary care consultations compared to asympto

Aetiology-Guided (Stratified) Care Improves Angina in MINOCA: Key Findings from the PROMISE Trial
CardiologyanginaMINOCA

Aetiology-Guided (Stratified) Care Improves Angina in MINOCA: Key Findings from the PROMISE Trial

By MedXY|Nov 29, 2025

The PROMISE randomized trial shows that comprehensive, aetiology‑guided management of MINOCA significantly improves angina-related health status at 12 months versus standard care, supporting systematic diagnostic evaluation and individualiz

Routine Coronary Function Testing in ANOCA Improves Symptoms: Key Results from the ILIAS ANOCA Trial
CardiologyanginaANOCA

Routine Coronary Function Testing in ANOCA Improves Symptoms: Key Results from the ILIAS ANOCA Trial

By MedXY|Nov 28, 2025

The ILIAS ANOCA randomized trial shows that routine invasive coronary function testing (CFT) during angiography in patients with angina and non‑obstructive coronary arteries (ANOCA) is feasible, safe, yields a high diagnostic rate of vasomo

Endotyping-informed CMR-guided care markedly improves angina and quality of life in patients with chest pain and no obstructive CAD
CardiologyanginaINOCA

Endotyping-informed CMR-guided care markedly improves angina and quality of life in patients with chest pain and no obstructive CAD

By MedXY|Nov 13, 2025

A multicenter randomized trial shows stress CMR myocardial perfusion mapping with endotype-directed therapy reclassified diagnosis in 53% of patients with unobstructed coronaries and produced a large, clinically meaningful 21-point improvem

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